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The new Matrix-Assisted Laser Desorption Ionisation time-of-flight mass spectrometry based test for hbA1c and genetic hemoglobin variants is intended for use on the MALDI Biotyper platform is likely to provide specificity, accuracy, speed of analysis and cost per analysis.
Abbreviations 2-DE: 2 Dimensional electrophoresis CE: Capillary electrophoresis ESI: Electrospray ionisation LC: Liquid chromatography MALDI: Matrix assisted laser desorption/ionisation MELDI: Material-enhanced laser desorption/ionization MS: Mass spectroscopy SELDI: Surface enhanced laser desorption ionisation TOF: Time of flight.
Fenn, Virginia Commonwealth University, Richmond, VA, and Koichi Tanaka of Shimadzu Corp., Kyoto, Japan, "for their development of soft desorption ionisation methods for mass spectrometric analyses of biological macromolecules." The other half is for Kurt Wuthrich, from the Swiss Federal Institute of Technology (ETH) in Zurich and The Scripps Research Institute in the U.S., "for his development of nuclear magnetic resonance spectroscopy for determining the three-dimensional structure of biological macromolecules in solution."
It covers techniques such as electron and chemical jonisation and newer soft ion-isation techniques such as matrix-assisted laser desorption ionisation and electrospray.