To make observable signals less and sharper, we used segmental isotope-labeling and protein deuteration
along with two-dimensional NMR at high magnetic field.
This Note surveys the courts' approaches to other obviousness challenges in the chemical arts in an attempt to discern how they will address the deuteration
of known compounds in an obviousness inquiry.
However, the deuteration
itself may have altered the chemistry and physics of the individual components.
However, the well-resolved OH deformation bands at 915 [cm.sup.-1] (Al-Al-OH) and 843 [cm.sup.-1] (Al-Mg-OH) are more characteristic, their assignments were confirmed by deuteration
(Russel, Farmer and Velde, 1970).
This distinctive scattering characteristic allows researchers to highlight specific groups in complex molecules by selective deuteration
and leads to major advances in our understanding of structures that occur, for example when viruses attack membranes, or when polymer layers interdiffuse.
The product retention times coincided with those of the ISs but were distinguished by different m/z values because of deuteration
(see online Supplemental Table 1).
combined with X-ray and neutron reflectivity has been used to determine the extent of probe segregation to an interface in ultra-thin polymer films as a function of the number of thermal cycles.
Determination of the cation orientation was made possible by selective deuteration
of the methyl groups of the quaternary nitrogen.
His technical interests include aspects of reactor design insulated pressure tubes, deuteration
of ion-exchange resin, pressure tube design and organic coolants.
In this work, selective deuteration
of the methyl groups of the quaternary nitrogen enabled the orientation of this group to be determined.