Metal-induced developmental toxicity
in mammals: A review.
The NTP reference guideline for reproductive and developmental toxicity
, the NTP's Modified One-Generation (MOG) Reproduction Study (NTP 2011a), employs pregnant animals with exposures beginning at implantation with continued dosing of dams throughout gestation and lactation (Foster 2014).
evaluation of triclopyr butoxyethyl ester and triclopyr triethylamine salt in the CD rat.
The drug caused minor developmental toxicity
in rat fetuses that was reversed after birth, and shortening of the gestation period.
Pretreatment with Periodate - Oxidized Adenosine Enhances Developmental Toxicity
of Inorganic Arsenic in Mice.
In addition to elevated cancer risk and disruption of the endocrine system, growing evidence supports developmental toxicity
from prenatal or early postnatal exposure to PAHs (Perera et al.
Moreover, the underlying mechanisms behind the developmental toxicity
of compounds known to have a teratogenic potential has solely partially elucidated if any (1).
Short- to mid-term exposures have shown neurotoxicity, developmental toxicity
, immunotoxicity and endocrine disruption leading to toxic end points.
The International Scientific Committee at the International Conference on Fetal Programming and Developmental Toxicity
(Faroe Islands, May 2007) stated in a position paper: "The old paradigm, developed over four centuries ago by Paracelsus, was that 'the dose makes the poison.
This study confirms that, as we have suspected, exposure to (perfluorooctane sulfonate and perfluorooctanoate) is fairly universal; this is of particular concern because of the potential toxicity, especially developmental toxicity
, for these chemicals and the lack of information about health risks at these exposure levels," said APHA member Lynn Goldman, MD, MPH, co-author of the study.
He is not aware of any developmental toxicity
reported in association with these agents, other than indirect effects related to severe maternal hypoglycemia.
NTP-CERHR Expert Panel Report on the Reproductive and Developmental Toxicity
of Soy Formula.