Dextran

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dextran

[′dek ‚stran]
(biochemistry)
Any of the several polysaccharides, (C5H10O5)n , that yield glucose units on hydrolysis.

Dextran

 

(C6H10O5)n, a polysaccharide of bacterial origin, a polymer of glucose. The molecular weight can be as high as 10,000,000. In the linear part of the dextran molecule the glucose residues are joined by bonds between the first and sixth carbon atoms; branching is due to bonds between the first and fourth, first and third, and first and second atoms. Dextran is obtained by growing microorganisms of the genus Leuconostoc in an artificial culture medium. Dextran, in the form of a partially hydrolyzed solution with not less than 90 percent 1.6 linkages and a molecular weight of about 60,000 is used clinically as a blood plasma substitute. The preparation provides for a normal osmotic pressure corresponding to that of blood. Modified dextran, so-called Sephadex, is used in chromatography.

References in periodicals archive ?
9% NS Blood DIO Plasma Dextran 40 Properties Causes fluid to move Increases intravascular out of cells and into space without excess intravascular space fluid Causes intravascular expansion Useful for Head Trauma Edema Increased ICP Expansion of intravascular Hyponatremia spaces Edema Improving tissue perfusion Acid/base imbalances Prevention of vasospasm Severe anemia Cautious In Increased PAWP CHF Increased CVP Hypervolemia JVD Hemoconcentration Hemoconcentration * D5W is isotonic in the bag, but quickly becomes hypotonic when administered intravascularly (Phillips, 2010).
Dextran 75 and dextran 40 (500 cc/day) pentoxyphyline (8 mg/day), ampicillin-sulbactam (100 mg/kg/day), paracetamol (500 mg tablet 2x1) and fluid treatment with 2500 cc/[m.
Total paracentesis with dextran 40 vs diuretics in the treatment of ascites in cirrhosis: a randomized controlled study.
33 g/L), dextran 40 (10 g/L), 40 g/L bovine serum albumin, heparin (2.