Dextran

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dextran

[′dek ‚stran]
(biochemistry)
Any of the several polysaccharides, (C5H10O5)n , that yield glucose units on hydrolysis.

Dextran

 

(C6H10O5)n, a polysaccharide of bacterial origin, a polymer of glucose. The molecular weight can be as high as 10,000,000. In the linear part of the dextran molecule the glucose residues are joined by bonds between the first and sixth carbon atoms; branching is due to bonds between the first and fourth, first and third, and first and second atoms. Dextran is obtained by growing microorganisms of the genus Leuconostoc in an artificial culture medium. Dextran, in the form of a partially hydrolyzed solution with not less than 90 percent 1.6 linkages and a molecular weight of about 60,000 is used clinically as a blood plasma substitute. The preparation provides for a normal osmotic pressure corresponding to that of blood. Modified dextran, so-called Sephadex, is used in chromatography.

References in periodicals archive ?
Extract (E) and fractions (F I, F II and F III) and standard glycosaminoglycan chondroitin-4-sulfate (C-4-S, 40 kDa), chondroitin-6-sulfate (C-6-S, 60 kDa), dextran sulfate (DexS, 8 kDa) and/or unfractionated heparin (UHEP, 14 kDa) present on gels stained with 0.
fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice.
Biomolecular interaction Calorimetric technique [beta]-lactoglobulin and Chitosan ITC [beta]-lactoglobulin-sodium alginate ITC BSA and Dextran Sulfate DSC [beta]-lactoglobulin and Dextran DSC Sulfate WPI and Chitosan ITC Casein and Dextran DSC [beta]-lactoglobulin and Gum Arabic ITC [beta]-lactoglobulin and Carrageenan ITC Soy protein and Chitosan DSC Pectin and WPI DSC Hyaluronic Acid and Lysozyme DSC e ITC Soy protein and Gum Arabic ITC [beta]-lactoglobulin and Lactoferrin ITC Polysaccharides (carrageenan and CMC) DSC and soy proteins Biomolecular interaction Thermodynamic parameters [beta]-lactoglobulin and Chitosan 72 and [DELTA]H [beta]-lactoglobulin-sodium alginate [DELTA]H BSA and Dextran Sulfate [T.
The process used may include adsorption on calcium phosphate/hydroxyapatite, a hydrophobic matrix, a chelate matrix, a matrix on which heparin or a substance related to heparin, such as heparin sulfate or dextran sulfate, is immobilized, or a matrix that is coated with an immobilized monoclonal or polyclonal antibody directed against the protein to be isolated, or F(ab) or F(ab).
These compounds, which had names like ribavirin, isoprinsosine, and dextran sulfate, were freely available in Mexico, the Far East, and Europe.
At the same time, researchers sounded the death knell for dextran sulfate, aone-promising AIDS treatment, and cautioned against bypassing standard procedures for drug approval.
NEW GLOUCESTER, Maine -- Sun Diagnostics' product offerings include ASSURANCE[TM] Interference Test Kit and Dextran Sulfate Sodium Salt.
Electrophoretic techniques on agarose gel and polyacrylamide gel (PAGE) were performed and sulfate and nonSPs were revealed by sequential staining with toluidine blue/stains-all (Sigma Chemical) (Volpi & Maccari, 2002) by comparison with the electrophoretic mobility of standard compounds dextran sulfate (~ 8 kDa), chondroitin4-sulfate (~ 40 kDa), chondroitin-6-sulfate (~ 60 kDa) (Rodrigues et al.
Study design: Evaluation of anti-inflammatory effect of MQEO using dextran sulfate sodium (DSS)-induced intestinal inflammation in mice and exploration of the mechanisms with THP-1 cells.
For example, L-arginine treatment ameliorated the disease activity index and epithelial permeability in mice treated with dextran sulfate sodium (DSS) due to reduced expression of proinflammatory cytokines and enhanced epithelial wound healing [9].
Essex Junction, VT, USA); chromogenic substrates S-2238, S-2222 and S-2302 (Chromogenix AB, Mondal, Sweden); low molecular weight dextran sulfate (8 kDa) and chondroitin-4-sulfate (40 kDa) from whale cartilage; chondroitin-6-sulfate (60 kDa) from shark cartilage; and other reagents were commercially purchased.
The mice were then fed water containing dextran sulfate sodium (DSS), a substance that induces colitis, to see whether IL-37 provided protection from intestinal inflammation.