Dextran

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dextran

[′dek ‚stran]
(biochemistry)
Any of the several polysaccharides, (C5H10O5)n , that yield glucose units on hydrolysis.

Dextran

 

(C6H10O5)n, a polysaccharide of bacterial origin, a polymer of glucose. The molecular weight can be as high as 10,000,000. In the linear part of the dextran molecule the glucose residues are joined by bonds between the first and sixth carbon atoms; branching is due to bonds between the first and fourth, first and third, and first and second atoms. Dextran is obtained by growing microorganisms of the genus Leuconostoc in an artificial culture medium. Dextran, in the form of a partially hydrolyzed solution with not less than 90 percent 1.6 linkages and a molecular weight of about 60,000 is used clinically as a blood plasma substitute. The preparation provides for a normal osmotic pressure corresponding to that of blood. Modified dextran, so-called Sephadex, is used in chromatography.

References in periodicals archive ?
Agarose (A, B) and polycrylamide (C, D, E) gel electrophoreses of Caulerpa cupressoides SPs fractions, obtained by DEAE-cellulose, and standard glycosaminoglycans chondroitin-6-sulfate (C-6-S, 60 kDa), chondroitin-4-sulfate (C-4-S, 40 kDa), dextran sulfate (DexS, 8 kDa), unfractionated heparin (UHEP, 14 kDa) present on gels were stained with 0.1% toluidine blue (a) or stains-all (b).
Substance-P alleviates dextran sulfate sodium-induced intestinal damage by suppressing inflammation through enrichment of M2 macrophages and regulatory T cells.
Ohkusa, "Production of experimental ulcerative colitis in hamsters by dextran sulfate sodium and changes in intestinal microflora," Nihon Shokakibyo Gakkai Zasshi, vol.
Tsuji et al., "Impact of adrenomedullin on dextran sulfate sodium-induced inflammatory colitis in mice: insights from in vitro and in vivo experimental studies," International Journal of Colorectal Disease, vol.
Feng et al., "Baicalin down regulates the expression of TLR4 and NFkB-p65 in colon tissue in mice with colitis induced by dextran sulfate sodium," International Journal of Clinical and Experimental Medicine, vol.
Marine hydroquinone zonarol prevents inflammation and apoptosis in dextran sulfate sodium-induced mice ulcerative colitis.
The new antibodies are part of the company's lipoprotein offering, also including the LipoSep IP (LS-01) Immunoprecipitation reagent for isolation of HDL particles, as well as the Dextran Sulfate (DS109), with a 40,000 MW, which is used to identify HDL concentration by chemical precipitation.
When transplanted into mice with dextran sulfate sodium-induced colitis, N-GMSCs showed superior effects in ameliorating inflammatory-related disease phenotype in comparison with the M-GMSC treatment group.
The purpose of this study is to investigate possible inhibitory effect of AX against inflammation-related mouse colon carcinogenesis and dextran sulfate sodium (DSS)-induced colitis in male ICR mice.
We then diluted the concentrated samples 1:10 with the normal isoform of prion protein substrate containing 0.5% potassium dextran sulfate. Using the sPMCA technique as described (1), we amplified the samples in 3-8 tubes, and we used Western blot to analyze the proteinase K-treated sPMCA products (2).
To make this discovery, scientists used a chemically induced model of colitis with Dextran sulfate sodium (DSS), researchers administered an oral placebo to one group of mice, and the other group of mice was given an oral dose of apple polyphenols every day during the course of the disease.