diacylglycerol


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Related to diacylglycerol: Protein kinase C, triacylglycerol

diacylglycerol

[‚dī·ə·səl′glis·ə‚rōl]
(biochemistry)
A product of the cleavage of membrane-associated phospholipid by phospholipase C that activates isozymes of protein kinase C, an important regulator of cell function.
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References in periodicals archive ?
Reciprocal responses to dietary diacylglycerol of hepatic enzymes of fatty acid synthesis and oxidation in the rat.
Boden, "Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and I[kappa]B-[alpha]," Diabetes, vol.
In addition to inflammatory signaling, chronic tissue exposure to high levels of saturated fatty acids may promote insulin resistance by increasing tissue content of the lipids diacylglycerol and ceramides.
Diacylglycerols derived from membrane phospholipids are metabolized by lipases in A10 smooth muscle cells.
Farese Jr., "Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme A: diacylglycerol acyltransferase 1 in white adipose tissue," Diabetes, vol.
They tended to accumulate neutral lipids, including monoacylglycerol, diacylglycerol, triacylglycerol, free fatty acids, and alkyl chain.
Meanwhile, overexpression of diacylglycerol acyltransferases (DGATs) has been shown to increase oil content in Arabidopsis (Jako et al., 2001) and soybean (Lardizabal et al., 2008).
Monogalactosyl diacylglycerol, a replicative DNA polymerase inhibitor, from spinach enhances the anti-cell proliferation effect of gemcitabine in human pancreatic cancer cells.
(23,24) The rise in the intracellular calcium concentration causes the activation of phosphatidylinositol 4,5-bisphosphate ([PIP.sub.2])-specific phospholipase C and hydrolysis of [PIP.sub.2] and production of two second messengers: diacylglycerol and inositol 1,4,5-triphosphate([IP.sub.3]).
R-GECO can be paired with cADDis, the green-fluorescent cAMP sensor, or the green-fluorescent Upward and Downward DAG sensors to simultaneously detect both Ca2+ and cyclic AMP or Ca2+ and diacylglycerol in living cells.
The scientists produced the structural map of this nanomachine -- diacylglycerol kinase -- by using a "hit and run" crystallography technique.