specificity

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specificity

[‚spes·ə′fis·əd·ē]
(chemistry)
The selective reactivity that occurs between substances, such as between an antigen and its corresponding antibody.
References in periodicals archive ?
The reactivity threshold (Figure) is used to categorize a serum as reactive or nonreactive and to determine the diagnostic sensitivity (DSN) and diagnostic specificity (DSP) of the assay.
Graeme Eisenhofer: For borderline test results, it is important that follow-up tests have at least equal diagnostic sensitivity and, ideally, better diagnostic specificity than the initial screening test.
In contrast, the high diagnostic specificity indicates that the TMPRSS2-ERG gene fusion could be used as a noninvasive adjunct marker in urine, in combination with other markers such as PSA and PCA3, to improve overall diagnostic accuracy (11).
Diagnostic sensitivity, 100 X [TP/(TP + FN)]; diagnostic specificity, 100 X [TN/(TN + FP)]; and efficiency, 100 X [(TP + TN)/(TP + TN + FP + FN)] were calculated at multiple screening and confirmation cutoffs.
Methylated markers BMP3, NDRG4, VIM, and TFPI2, respectively, detected 84%, 92%, 86%, and 92% of colorectal cancers and 68%, 76%, 76%, and 88% of advanced adenomas at a diagnostic specificity cutoff of 95%.
In the study reported here, we compared the diagnostic sensitivity and diagnostic specificity of serum creatinine and Cys for early CIN prediction in a population of patients undergoing coronary angiography and interventions who were at risk for AKI.
Percentages for samples from individuals exceeding the various cutoffs, diagnostic sensitivity, diagnostic specificity, positive predictive value, and negative predictive value (with 95% CIs) were calculated for the combined serious outcome (death, MI, heart failure, serious arrhythmia, refractory ischemic cardiac pain).
John Blackwood: The challenge is to demonstrate an adequate level of diagnostic specificity at the 99th-percentile upper reference limit.

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