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Deposition of amyloid in one or more organs of the body.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



or amyloid dystrophy, a disorder of protein metabolism accompanied by the formation within tissues of a specific protein polysaccharide complex known as amyloid. The progress of the disease is associated with distortion of the protein-synthesizing function of the reticuloendothelial system and with accumulation of anomalous proteins in the blood plasma which act as autoantigens and also stimulate the formation of autoantibodies. As a result of antigen-antibody interaction, there is deposition of widely dispersed proteins which figure in the formation of amyloid. Once deposited in tissues, such as vascular and gland walls, the amyloid displaces functionally specialized elements of the organ; this process leads to the destruction of the organ.

Several types of amyloidosis are recognized: primary, secondary, and senile amyloidosis; amyloidosis with multiple myeloma; and localized tumorlike amyloidosis. Primary amyloidosis has no connection with any other disease; it affects mainly the cardiovascular system, alimentary tract, muscles, and skin. Secondary amyloidosis develops subsequent to other diseases which are accompanied by prolonged suppuration and tissue breakdown, such as tuberculosis, syphilis, and rheumatoid arthritis. It most often affects the spleen, liver, kidneys, adrenal glands, and intestines. Senile amyloidosis usually involves the heart. Amyloidosis may be either general or localized. Im-munodepressive and hepatic preparations are used in its treatment.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Dialysis-related amyloidosis: international symposium, Nagoya, May 28-29, 1994.
Teaching on appropriate pain relief medications is imperative, especially if it is dialysis-related amyloidosis. The medications must also be kidney friendly.
Symptoms of dialysis-related amyloidosis in diabetic patients.
[6] Nonstandard abbreviations: /[[beta].sub.2]M, [[beta].sub.2]-microglobulin; CHD, chronic hemodialysis; DRA, dialysis-related amyloidosis; IA-LC-MS, immunoaffinity-liquid chromatography-mass spectrometry; [DELTA]K58[[beta].sub.2]M, cleaved [[beta].sub.2]microglobulin lacking lysine-58; mAb, monoclonal anfibody; and PBS, phosphate-buffered saline.