dicentric


Also found in: Dictionary, Medical.

dicentric

[dī′sen·trik]
(cell and molecular biology)
Having two centromeres.
References in periodicals archive ?
To determine whether dicentric frequency followed a Poisson distribution as expected for acute X-ray irradiation, the dispersion index ([[sigma].sup.2]/y) and the normalized unit of this index (u) were obtained for each dose using an equation described in the IAEA manual where N indicates the number of cells analyzed and X is the number of dicentrics detected.
The analysis of structural CA included breaks, dicentrics, and rings.
Evidence for structural heterogeneity from molecular cytogenetic analysis of dicentric Robertsonian translocations.
Dicentric chromosomes: unique models to study centromere function and inactivation.
Dicentric chromosomes (DC), acentric fragments (AF), and chromatid breaks (ChB) were the indices used to evaluate the chromosomal aberrations during the present study.
Dicentric, premature chromosome condensation fragment and micronucleus frequencies fall with the turnover of lymphocytes, enabling application of these assays for dose assessment in more recent exposures.
Two chromosomes are deemed included when the following structural aberration existed: dicentric chromosome and translocation.
The dicentric chromosomes in the population are indicating a previous exposure to radiation.
Bridges are observed between two nuclei that are not too close or overlaid (FENECH et al., 2003), and originate from dicentric chromosomes whose centromeres are pulled to opposite poles during anaphase.
NPBs and NBUDs), cytotoxicity (necrosis and apoptosis) and mitotic status (scoring mono and multinucleated cells), MNi are formed as a result of chromosome fragmentation or loss, NPBs are dicentric chromosomes reflecting telomere end-fusions or DNA mis-repair and NBUDs represent extrusion of amplified DNA indicating gene amplification and/or DNA repair complexes (Shimizu et al., 1998; Fenech, 2000).
The aberrations were classified into 8 groups: chromosome gap (G), chromosome break (B), dicentric (D), ring (R), chromatid gap (g), chromatid break (b), multiple aberrations (MA), and acentric fragment (AF).
observed a mean frequency of dicentric chromosomes more than twice as high (0.38 [+ or -] 0.15 per 100 cells) as the spontaneous frequency determined in unirradiated mice of similar age (556 days; 0.17 [+ or -] 0.14 per 100 cells).