dicentric

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dicentric

[dī′sen·trik]
(cell and molecular biology)
Having two centromeres.
References in periodicals archive ?
Dicentric chromosomes (DC), acentric fragments (AF), and chromatid breaks (ChB) were the indices used to evaluate the chromosomal aberrations during the present study.
DC, dicentric chromosome; AF, acentric fragments; ChB, chromatid breaks.
Dicentric, premature chromosome condensation fragment and micronucleus frequencies fall with the turnover of lymphocytes, enabling application of these assays for dose assessment in more recent exposures.
Dicentric frequencies in PBL show a clear linear quadratic dose-effect relationship up to 5 Gy for acute photon exposures.
The dicentric chromosomes in the population are indicating a previous exposure to radiation.
Scoring of dicentrics in peripheral blood lymphocytes cultured in vitro is interpreted in terms of the absorbed radiation dose with reference to a dose-response calibration curve generated by irradiating blood samples from healthy, unexposed donors with different absorbed doses of a defined quality of radiation.
In addition to dicentrics, the numbers of centric rings, excess acentric fragments and chromosome breaks were recorded.
To determine whether dicentric frequency followed a Poisson distribution as expected for acute X-ray irradiation, the dispersion index ([[sigma].sup.2]/y) and the normalized unit of this index (u) were obtained for each dose using an equation described in the IAEA manual where N indicates the number of cells analyzed and X is the number of dicentrics detected.
Dicentrics, a chromosome-type translocation, were rarely observed; therefore, this type of abnormality was not meaningful for further evaluation.
Our data also showed that XPD 312 Asn and XPD 751Gln are associated with slightly reduced aberration frequencies in X-ray-challenged cells, with more reduction in dicentrics for the combined heterozygous and homozygous variant XPD 312Asn and XPD 751Gln (Table 2).
The analysis of structural CA included breaks, dicentrics, and rings.
However, they took only dicentric and ring chromosomes into account, which were not findings reported in our study.