Ketoconazole has a distinct advantage over diethylstilbestrol
in that the former drug reduces testosterone to castrate levels within 48 hours compared with 2 weeks for diethylstilbestrol
Molecular feminization of mouse seminal vesicle by prenatal exposure to diethylstilbestrol
: altered expression of messenger RNA.
METHODS: Female CD-1 mice that were exposed to BPA at 0, 25 ng, 250 ng, or 25 [micro]g/kg body weight (BW)/day or diethylstilbestrol
(DES) at 10 ng/kg BW/day (positive control) from gestational day 8 through day 16 of lactation were continuously housed with proven breeder males for 32 weeks starting at 2 months of age.
Washington, May 22 (ANI): Adult women who were exposed prenatally to bisphenol-A (BPA, a chemical commonly used in plastic food containers) or diethylstilbestrol
(DES) could be at increased risk of breast cancer, according to a new study in mice.
"Wonder Drug" is a "scientific drama" of how DES (diethylstilbestrol
), the world's first drug disaster, harms the lives of a pharmaceutical executive, a feminist doctor and a 30-something newlywed.
* Medical research indicates that daughters of women who took the drug diethylstilbestrol
(DES) during the years 1938 through 1971 to prevent miscarriage have an increased risk of developing this disease.
A new Web site provided by he Centers for Disease Control and Prevention offers educational resources about health risks associated with diethylstilbestrol
Women in this age group who have a history of cervical cancer, in utero exposure to diethylstilbestrol
(DES), or who are immunocompromised should continue screening as long as they are in "reasonably good health and do not have a life-0limiting chronic condition," the new ACS guidelines state.
In the 1940s, physicians began giving diethylstilbestrol
(DES) to pregnant women, several million of them in the United States alone.
(DES), dexamethasone (DEX), cyclophosphamide (CPS), and 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD) are environmental chemicals that produce immunotoxic effects in the thymus, but the mechanism of toxicity has been considered to be different for each compound.
Inspired by real events, "Wonder Drug" is a scientific drama of how DES (diethylstilbestrol
), the world's first drug disaster, harms the lives of a pharmaceutical executive, a feminist doctor and a 30-something newlywed across different decades.
"Our serial lot analyses found that PC SPES lots manufactured from 1996 through the middle of 1999 contained indomethacin and diethylstilbestrol
and that lots manufactured from the middle of 1999 through August 2001 contained progressively lower amounts of both substances and also had correspondingly decreased antineoplastic activity and estrogenicity," said Dr.