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see thyroid glandthyroid gland,
endocrine gland, situated in the neck, that secretes hormones necessary for growth and proper metabolism. It consists of two lobes connected by a narrow segment called the isthmus. The lobes lie on either side of the trachea, the isthmus in front of it.
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in man, enlargement of the thyroid gland caused by the proliferation of its functional lymphoid tissue (parenchyma) or of its connective-tissue stroma. The proliferation of thyroid epithelium may embrace the entire thyroid parenchyma (diffuse goiter), or it may originate in a particular portion of the parenchyma (nodular goiter). Slight enlargement of the gland may occur in puberty or during menstruation, pregnancy, and lactation. Goiter may be associated with a number of conditions—diffuse toxic goiter, thyroiditis, thyroid tumor, and sporadic and endemic goiter.

A goiter may be unilateral or bilateral. Most often it is found in the neck; sometimes it is located behind the sternum (substernal goiter). A goiter usually alters the contours of the neck; although with substernal and deep-lying goiters the contours of the neck may remain normal. A goiter results in malfunction of the thyroid gland, but in the euthyroid form there need not be any functional impairment. Sporadic goiter is found in a number of localities and is caused by an endogenous (depending on internal factors) iodine deficiency in the body. Endemic goiter is found in certain biogeochemical areas where there is an insufficiency of iodine in the air, water, soil, and food products (instead of 200–220 μg, 20–80 μg of iodine or less enters the human body). Insufficiency of iodine in the environment may be aggravated by unfavorable exogenous (social, everyday, and sanitary-hygienic conditions) or endogenous (pregnancy, lactation, hypovitaminoses, helminthiases) factors. Iodine deficiency may result from infectious diseases or intoxications. A relative deficiency may occur when the ratio of iodine to certain chemical compounds (calcium, fluorine, and so forth) in the body is upset. Endemic goiter is found in almost every country, especially in mountainous regions, valleys, foothills, and watersheds and in swampy, sandy, and peaty regions. It is almost never found in chernozem zones.

Goiter prevention includes correcting unhealthy conditions in the throat and mouth, vermifuge treatment, and improvement of the conditions of sanitation and hygiene of daily life (keeping dwellings clean, maintaining the water supply properly, sound nutrition); individual and group iodine prophylaxis (iodized table salt); and early detection and dispensary observation of goiter patients. Treatment, depending on the form and symptoms of goiter, includes iodine preparations, thyroidin, triiodothyronine, and diiodothyrosine. Surgery is indicated for nodular and mixed goiter; it is also recommended for diffuse goiter if more conservative treatment proves ineffective.



An enlargement of all or part of the thyroid gland; may be accompanied by a hormonal dysfunction.


(US), goiter
Pathol a swelling of the thyroid gland, in some cases nearly doubling the size of the neck, usually caused by under- or overproduction of hormone by the gland
References in periodicals archive ?
02) and among subjects without diffuse goiter compared with subjects with diffuse goiter (p = 0.
In 51% of the patients (n=103), diffuse goiter was detected.
The mechanism behind increased iodine-uptake-associated of diffuse goiter in GD is unknown, but several mechanisms could be involved.
Evaluate dominant or suspicious nodules further, while diffuse goiters without symptoms require no further evaluation and can be followed clinically (strength of recommendation [SOR]: C, expert opinion).
In addition, data were cross-classified by the following categorical variables reflecting status at the time of the first screening examination: oblasr of residence (Zhytomyr, Kyiv, Chernihiv), type of residence (urban/ rural), smoking status (yes/no), family history of thyroid disease (yes/no), presence of diffuse goiter on palpation (yes/no), and ultrasound-detected nodules (yes/no).
Specifically, the ERR per gray tended to increase with decreasing age at exposure and to be higher in females than in males; it was elevated throughout the observation period and did not vary meaningfully by time since exposure; and ERR per gray was somewhat higher for those who did not take iodine prophylaxis in 1986 or had diffuse goiter or higher levels of serum TG at the first screening examination.
12-14 years after the accident), we found that the I-131-related risks tended to be higher among individuals with diffuse goiter or with higher levels of serum TG, but not in individuals with lower concentration of urinary iodine.
Children present with diffuse goiters, while adults present with nodular goiters.
Of the breast cancer patients, 12 had diffuse goiters and 13 had nodular goiters, compared to 1 and 2 of the control patients, respectively, both significant differences.

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