digitoxigenin


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digitoxigenin

[‚dij·ə‚täk·sə′jen·ən]
(organic chemistry)
C23H34O4 The steroid aglycone formed by removal of three molecules of the sugar digitoxose from digitoxin.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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The more known cardiac glycosides of the plant are oleanderin, folinerin and digitoxigenin. The toxicity of oleander cardiac glycosides is related to their ability in inhibition plasmalemmal sodium, potassium adenosine triphosphatase ([Na.sup.+], [K.sup.+]- ATPase), leading to sodium accumulation in excitable cells such as nervous tissue and myocardium [9,10].
Further deglycosylation to monodigitoxoside (mono-DTN) and digitoxigenin has been documented in mice, rabbits, and guinea pigs [5].
Initially, we expected the deglycosylated congeners of digitoxin (i.e., bis-DTN, mono-DTN, and digitoxigenin) to be the sources of discrepancy.
Chemical structure and pharmacological activity of some derivatives of digitoxigenin and digoxigenin.