Diagnosis of 5[alpha]-reductase 2 deficiency: is measurement of
dihydrotestosterone essential?
Saw palmetto does this by moderately inhibiting 5-alpha reductase (which activates testosterone to the much more potent
dihydrotestosterone form) and by antagonizing the androgen receptor.
Ogata, "Backdoor pathway for
dihydrotestosterone biosynthesis: implications for normal and abnormal human sex development," Developmental Dynamics, vol.
NF/PB, [beta]-naphtoflavone/phenobarbital; AR, androgen receptor; BaP, benzo(a)pyrene; BPA, bisphenol A; CALUX, chemically activated luciferase gene expression; CYP, cytochrome P450; DHT,
dihydrotestosterone; DMSO, dimethylsulfoxide; E2, 17[beta] estradiol; EAS, endocrine active substances; [EC.sub.50], half-maximal effective concentration; EDTA, ethylenediaminetetraacetic acid; ERa, estrogen receptor [alpha]; HPTE, 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; [IC.sub.50], half-maximal inhibitory concentration; MC, methoxychlor; RLU, relative light unit; S9, hepatic 9 000 x G supernatant; STZ, stanozolol
Here, in this study, to aid the research and development of steroidal antiandrogens, we investigated the relationships between a series of 7[alpha]-substituted
dihydrotestosterone derivatives and corresponding antiandrogen activities.
Dutasteride is more potent that finasteride and also inhibits type 1 alpha-reductase; both of these enzymes convert testosterone into the more potent
dihydrotestosterone. The side-effect profile is more moderate than that of spironolactone, but both of the drugs have had mixed results in clinical trials.
Dutasteride is more potent than finasteride and also inhibits type 1 alpha-reductase; both of these enzymes convert testosterone into the more potent
dihydrotestosterone. The side-effect profile is more moderate than that of spironolactone, but both of the drugs have had mixed results in clinical trials.
Dr Terry Loong, cosmetic doctor, hormonal expert and author of The Hormonal Acne Solution, says triggers include: A high-sugar |diet: Sugar is inflammatory and increases oil production by converting testosterone (a male hormone which governs the oil our skin produces) to a more potent
dihydrotestosterone.
Sophie Tinklin Date of violation: 12/07/2012 Sport: Amateur Boxing National Governing Body: Welsh Amateur Boxing Association Rule violated: Possession of prohibited substances, trafficking or attempted trafficking Class of drug: Anabolic agents, hormone and metabolic modulators Substance: Clomiphene,
Dihydrotestosterone, Mesterolone, Methyltestosterone, Nandrolone, Oxymetholone, Stanozolol, Testosterone, Trenbolone Start date of sanction: 19/02/2014 End date of sanction: 18/02/2018 Summary: Gwent Police were tipped off about large amounts of money - more than PS40,000 - being sent in the post from an address in Risca.
It is reported that association of prostate cancer is linked with the increasing levels of
dihydrotestosterone, and soybean isoflavones are known to inhibit 5alpha-reductase, which is involved in the conversion of testosterone to
dihydrotestosterone.
"Genetics is mostly the root cause of hair loss, regardless of where you live and the hormone,
Dihydrotestosterone (DHT), is the biggest culprit when it comes to androgenic alopecia."