Peak identities are as follows: (1) dibutyl phthalate (DBP); (2) benzyl butyl phthalate (BBP); (3) bis(2-ethylhexyl) adipate (DEHA); (4) bis(2-ethylhexyl) phthalate (DEHP); (5) di-n-octyl phthalate (DNOP); (6) dioctyl terephthalate (DOTP); (7) diisononyl phthalate (DINP); (8) diisodecyl phthalate
(DIDP); IS, benzyl benzoate (BB).
(DIDP) was used as the general-purpose plasticizer.
Experimentation was conducted with diisodecyl phthalate
(DIDP) and diisononyl phthalate (DINP) as potential replacements for DOP.
(a) MCPP is a metabolite of DOP, and is also a minor metabolite of diisooctyl phthalate, diisodecyl phthalate
, DiNP, DEHP, BBzP and DBP (dibutyl phthalate).
High-molecular-weight phthalates, such as butylbenzyl phthalate (BBzP), di(2-ethylhexyl) phthalate (DEHP), diisononyl phthalate (DiNP), and diisodecyl phthalate
(DiDP), are primarily used as plasticizers in polyvinyl chloride (PVC) applications found in building materials, cables and wires, toys, and food packaging (Schecter et al.
Several phthalates, including diisodecyl phthalate
(DIDP) and phthalate metabolites such as MEHP, can activate peroxisome proliferator-activated receptors that participate in a range of cellular processes including positive and negative regulation of inflammation (Cho et al.
MCPP is a metabolite of dioctyl phthalate (DOP), but also a minor metabolite of diisooctyl phthalate (DiOP), diisodecyl phthalate
(DiDP), DiNP, DEHP, butylbenzyl phthalate (BBzP), and DBP, making it difficult to relate this metabolite to exposure to any specific phthalate.
BACKGROUND: High-molecular-weight phthalates, such as diisononyl phthalate (DINP) and diisodecyl phthalate
(DIDP), are used primarily as polyvinyl chloride plasticizers.
The following 11 phthalate metabolites were measured at the CDC (Atlanta, GA, USA): mono(2-ethylhexyl) phthalate (MEHP), monobenzyl phthalate (MBzP), MBP, MEP, mono-isobutyl phthalate (MiBP), three oxidized metabolites of DEHP [mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-ox-ohexyl) phthalate (MEOHP), and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP)], mono(3-carboxypropyl) phthalate [MCPP; an oxidized metabolite of both DBP and di-n-octyl phthalate (DOP)], and monocarboxyisooctyl phthalate (MCOP) and monocarboxyisononyl phthalate (MCNP) (oxidized metabolites of diisononyl phthalate and diisodecyl phthalate
Also, the European Parliament voted in 2005 to ban the use of three phthalate plasticizers (DEHP, di-n-butyl phthalate, and benzyt butyl phthalate) in toys and child care items, and to prohibit the use of three others (diisononyl phthalate, diisodecyl phthalate
, and di-n-octyl phthalate) in toys and child care items that children can put in their mouths.
NTP-CERHR Expert Panel Report on Diisodecyl Phthalate
. Research Triangle Park, NC:National Toxicology Program, Center for the Evaluation of Risks to Human Reproduction.