Folding and dimerization
kinetics of bone morphogenetic protein-2, a member of the transforming growth factor-beta family.
Caption: FIGURE 2: Rosiglitazone-induced increase of GPR43 transcription requires dimerization
of PPAR and RXR in brown adipocytes.
(e) A split Cas9 composed of two separate fragments is fused to intein sequences that perform self-splicing upon dimerization
, leading to fully active Cas9 .
Release of GRP78 upon build-up of misfolded proteins, inadequate glucose levels, or other stressors enable dimerization
of PERK and its consequent auto-phosphorylation.
The monoclonal antibody pertuzumab (Perjeta, Hoffmann-La Roche, Basel, Switzerland) binds to the extracellular domain of HER2 and prevents the ligand-mediated dimerization
of HER2 with HER1 and HER3 by steric hindrance  (Figure 1).
An analogue of SFN, iberin [3-methylsulfinylpropyl isothiocyanate], showed a similar inhibitory effect on TLRs dimerization
. The mechanism of action was not selective, since the disruption of TLR dimerization
occurred on both TLR4 and TLR2, by covalent binding.
Bambara, "Mechanism of HIV-1 RNA dimerization
in the central region of the genome and significance for viral evolution," The Journal of Biological Chemistry, vol.
This is essential for the dimerization
and activation of these TLRs .
Unutmaz, "Absence of Leucine Zipper in the Natural FOXP3[DELTA]2[DELTA]7 Isoform Does Not Affect Dimerization
but Abrogates Suppressive Capacity," PLoS ONE, vol.
Human bradykinin B2 receptor sialylation and N-glycosylation participate with disulfide bonding in surface receptor dimerization
. Biochemistry 2006; 45(8): 2699-707.
This domain has been reported to be involved in the interaction with protein kinase R, which inhibits dimerization
of protein kinase R and stops its antiviral activity, whereas the interferon sensitivity determining region has been associated with resistance to IFN combination therapy.8
Summary: The rate constants for the dimerization
of the reduced products of methyl viologen dication (MV2+) of the processes (a) methyl viologen cation radical (MV+*), (EQUATION) and (EQUATION) and (b) methyl viologen neutral (MV), (EQUATION) and (EQUATION) were obtained through linear scan- / cyclic-voltammetry and the use of Olmstead-Hamilton-Nicholson theory.