dimethyl sulfoxide


Also found in: Dictionary, Medical, Wikipedia.
Related to dimethyl sulfoxide: Dimethyl sulfate, Dimethyl sulfide

dimethyl sulfoxide

[‚dī′meth·əl səl′fäk‚sīd]
(organic chemistry)
(CH3)2SO A colorless liquid used as a local analgesic and anti-inflammatory agent, as a solvent in industry, and in laboratories as a medium for carrying out chemical reactions. Abbreviated DMSO.
References in periodicals archive ?
Quercetin, [beta]-glucuronidase (HP-2), Ethylenediaminetetraacetic acid (EDTA), acetylcarnitine, leupeptin, bovine serum albumin (BSA), phenylmethylsulfonylfluoride (PMSF), Tris, dimethyl sulfoxide (DMSO), dithiothreitol (DTT), and carnitine acetyltransferase, Acetylcoenzyme, 2-Aminofluorene (2-AF) and N-acetyl-2-aminofluorene (2-AAF) were obtained from Sigma Chemical Co.
The major differences are the use of a lower MgCl2 concentration (0.625 mmol/L) and the use of dimethyl sulfoxide (DMSO) (12%) instead of formamide.
HPLC-grade dimethyl sulfoxide and HCl were obtained from Aldrich.
If this PCR is performed with reaction mixtures without dimethyl sulfoxide, the resulting melting points will be ~3[degrees]C higher.
We prepared stock solutions of F[B.sub.1], DEN, and CAT by dissolving 0.5 mg of each toxin in 30 [micro]L ethanol, 170 [micro]L dimethyl sulfoxide (DMSO), and 4.8 mL complete culture medium (CCM; minimum essential medium supplemented with 5% fetal calf serum, 1% Penstrep fungizone, and 1% L-glutamine), thus yielding a toxin concentration of 100 [micro]M.
(1), 1 [micro]L of reaction buffer (LightCycler DNA master hybridization probes 10 X buffer; Roche Diagnostics), 0.4 [micro]L of 25 mM MgCl, stock solution, 0.5 [micro]L of dimethyl sulfoxide, and 0.1 [micro]M each of the probes.
PENNSAID is the only FDA-approved topical NSAID in a vehicle solution containing dimethyl sulfoxide (DMSO), a known penetrating agent.
The PCR mixture contained 67 mM Tris-HCl (pH 8.4), 17 mM [(N[H.sub.4]).sub.2] S[O.sub.4], 6.7 mM Mg[Cl.sub.2], 0.1 g/L gelatin, 1 g/L Triton X-100, 0.4 [micro]M F6/F4, 80 [micro]M PCR-grade dNTPs (Roche Molecular Biochemicals), 2 [micro]L of dimethyl sulfoxide (Merck), and 1 [micro]L of thawed cell lysate.
After incubation for 1 hr at 37[degrees]C, the plates were washed again, and an enzyme substrate solution of 3,3',5,5'-tetramethyl-benzidine (TMB; Sigma Chemicals; 100 [micro]L/well; 6 mg/mL dimethyl sulfoxide) was added.
The drug combines the transdermal carrier (containing dimethyl sulfoxide, DMSO) with 1.5% diclofenac sodium, an NSAID and delivers the active drug through the skin directly to the site of inflammation and pain, concluded the company.