Dipeptides

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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Dipeptides

organic substances consisting of two amino acids connected by a peptide bond (—CO—NH—). Optically active, they form crystals of characteristic shape. The isoelectric point, color reactions, and other properties of dipeptides are determined by the amino acids that enter into their composition. Dipeptides are compounds intermediate between polypeptides and amino acids and are formed by the hydrolysis of proteins. Dipeptides consisting of the same L-amino acids but in different order yield isomers, for example, leucyl-alanine and alanyl-leucine. Natural dipeptides, such as carnosine and anserine, are found in animal tissues. A dipeptide molecule can be hydrolyzed by acids, alkalies, or enzymes (dipeptidases) to yield two amino acids.

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The generation of amino acids and dipeptides also contributes to the improvement of beef flavor.

Metabolomic approach to key metabolites characterizing postmortem aged loin muscle of Japanese Black (Wagyu) cattle

Dipeptide pathways, especially those involving glycine and glutamate metabolism, changed significantly across the three time points.

Metabolomics Profiling before, during, and after the Beijing Olympics: A Panel Study of Within-Individual Differences during Periods of High and Low Air Pollution

The smallest neutral dipeptide Gly-Gly was retained on the column after derivatisation with AccQ-Tag[TM] and it could be separated from the amino acid glycine, which forms both the amino acid components of this dipeptide.

Optimising methods for the recovery and quantification of di- and tripeptides in soil

Human GSS is a homodimer of two 52 kDa subunits that catalyzes the synthesis of glutathione by adding glycine to the dipeptide. GSS gene is located on chromosome 20q11.2 and includes 13 exons (1).

A case of severe glutathione synthetase deficiency with novel GSS mutations

Effects of supplementation with free glutamine and the dipeptide alanyl-glutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exercise.

CITOPROTECAO E INFLAMACAO: EFEITOS DA SUPLEMENTACAO COM GLUTAMINA E ALANINA SOBRE A LESAO MUSCULAR INDUZIDA PELO EXERCICIO RESISTIDO/Cytoprotection and inflammation: effects of glutamine and alanine supplementation upon resistance exercise-induced muscle damage

Hermann, "New dipeptide isosteres useful for the inhibition of HIV-1 protease," Bioorganic & Medicinal Chemistry Letters, vol.

Applications of Click Chemistry in the Development of HIV Protease Inhibitors

When an equimolar amount of complexes 1a-3a was reacted with Ac-L-His-Gly dipeptide, under the abovementioned experimental conditions, no reaction was observed by proton NMR spectroscopy for the complexes 2a and 3a during 48 h.

Hydrolysis of Methionine- and Histidine-Containing Peptides Promoted by Dinuclear Platinum(II) Complexes with Benzodiazines as Bridging Ligands: Influence of Ligand Structure on the Catalytic Ability of Platinum(II) Complexes

Gorbitz, "Nanotube formation by hydrophobic dipeptides," Chemistry--A European Journal, vol.

Self-Assembly of Diphenylalanine-Based Nanostructures in Water and Electrolyte Solutions

Since SLC15A3 is a late endosome and lysosome-located histidine and dipeptide transporter, we think SLC15A3 may use its transporter function to maintain endosome and lysosome conditions and consequently regulate the activity of DNA and RNA transporters on endolysosomal membrane, thereby affecting cytoplasmic DNA and RNA sensing.

The Solute Carrier Transporter SLC15A3 Participates in Antiviral Innate Immune Responses against Herpes Simplex Virus-1

To remedy this shortcoming, an easy and interpretable feature pertaining to the amino acid composition (AAC), dipeptide composition (DPC), and physicochemical property (PCP) were considered.

CryoProtect: A Web Server for Classifying Antifreeze Proteins from Nonantifreeze Proteins

Van Aalten, "Structure-based exploration ofcyclic dipeptide chitinase inhibitors," Journal of Medicinal Chemistry, vol.

Antagonistic Properties of Some Halophilic Thermoactinomycetes Isolated from Superficial Sediment of a Solar Saltern and Production of Cyclic Antimicrobial Peptides by the Novel Isolate Paludifilum halophilum

A part of dipeptide derivatives (5a-c) form six-membered ring compounds (2,5-diketopiperazine: DKP (11) [27]), which may not polymerize anymore.

Thermal Synthesis of Polypeptides from N-Butyloxycarbonyl Oligopeptides Containing Aspartyl Residue at C-Terminus

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