ORFs for the 2,3-diacylglucosamine-phosphate biosynthesis UDP-2 and 3-diacylglucosamine diphosphatase
(RWLH04621) were also identified.
Pioneering studies identified inositol glycans generated from Trypanosoma brucei, which displayed insulin mimetic action inhibiting lipolysis, glucose 6 phosphatase, and fructose-1,6 diphosphatase
, well-known insulin-mediated metabolic effects .
The commonest diagnoses were methyl malonic acIdaemia (n=2; 20%), non-ketotic hyperglycinaemia (n=7; 10%), fructose 1,6 diphosphatase
deficiency (n=1; 10%), and biotinidase deficiency (n=1; 10%).
The increase in the glycolytic enzyme fructose 1,6 diphosphatase
increases the pentose phosphate pathway.
The nucleoside diphosphates are converted to dianionic nucleoside monophosphates (used for the antiporter) and inorganic phosphate by a nucleoside diphosphatase
Induction of liver enzymes important in xenobiotic and thyroid hormone metabolism--for example, uridine diphosphatase
glucuronosyl transferases--can be measured in vitro in hepatocytes cultured with the test chemical.
The increase in glycolysis activates the enzyme fructose 1,6 diphosphatase
which activates the pentose phosphate pathway liberating NADPH.