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A prominent decrease in concentration of hepatic uridine diphosphate (UDP) glucuronic acid may be caused due to the absence of thyroid hormones, which is considerably low in infants as a result of the decrease in UDPG dehydrogenase activity.
Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. J Am Coll Cardiol 2010;56:919-33.
IPP isomerase (IDI) catalyzes the isomerization of IPP to DMAPP and condensation of two IPP molecules to form GPP (geranyl diphosphate).
[8], the sticky platelet syndrome is defined as a qualitative alteration of the platelet function and of autosomal dominant inheritance, characterized by platelet hyperaggregation in vitro with low concentrations of adenosine diphosphate (ADE) and/or epinephrine (EPI) but with normal aggregation in response to collagen, arachidonic acid, ristocetin, and thrombin [9].
Whitington et al., "Genetic predisposition to the metabolism of irinotecan (CPT-11): role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes," The Journal of Clinical Investigation, vol.
In humans, there are 10 genes belonging to the NM23 gene family, of which the two most abundantly expressed are NM23-H1 and NM23-H2 that encode the A and B subunits of nucleoside diphosphate kinase, respectively [9].
This involved the decoration of AR with Ti[O.sub.2] nanoparticles (Ti[O.sub.2]NPs) of an average particle size of 21 nm in presence of maleate diphosphate as flame retardant (FR).
It irreversibly inhibits the receptor of adenosine diphosphate (ADP), called P2Y12, expressed on the surface of platelets.
AbbVie was granted Orphan Drug Designation by the FDA for veliparib, an oral poly (adenosine diphosphate [ADP]ribose) polymerase (PARP) inhibitor, being studied in combination with chemotherapy or radiation for the treatment of advanced squamous non-small cell lung cancer (NSCLC).
The US Food and Drug Administration has granted Orphan Drug Designation to United States-based AbbVie's veliparib, an oral poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitor, it was reported yesterday.