Braguer et al., "Synergistic suppression of microtubule dynamics by discodermolide
and paclitaxel in non-small cell lung carcinoma cells," Cancer Research, vol.
Apart from paclitaxel, epothilones A and B, eleutherobin and discodermolide
have also been reported to bind to the taxol binding site (29).
combination relates to the US65415Q9 (2003) chemotherapy for synergistic effects the treatment of of Taxol cancer in combination with discodermolide
in treatment of cancer.
Thanks to the scientists chemical tool, researchers can now artificially produce this substance, called discodermolide
An example of such a compound is discodermolide
, a potential cancer drug extracted from a deep-water sponge.
Natural products effective against certain cancers have been identified: bryostatin from the colonial bryozoan, ecteinascidin from ascidians or sea squirts, and discodermolide
from deep-sea sponges.
The grant was awarded to Kosan to develop an efficient means of producing the polyketide discodermolide, a potential anti-cancer agent.
Discodermolide has been shown by researchers to inhibit cancer cells by the same mechanism as paclitaxel (the active ingredient in Taxol(R)), but also is effective against paclitaxel-resistant tumors.
Discodermolide initially was isolated from a deep sea marine sponge, but the amounts obtainable from that source are limited making the material extremely scarce.
Other natural products with the similar mechanism of action to taxol including epothilones, discodermolide
, eleutherobin, sarcadictyin and laulimalides, have been isolated and are in various stages of preclinical/clinical development (2).