Hypomagnesemia in GS is the consequence of a reduced expression of the epithelial Mg + transport channel TRPM6 in the distal convoluted tubule
, which results in decreased magnesium reabsorption (10).
In the present study, histological findings suggest tubular dilatation of both proximal and distal convoluted tubules
, in experimental group B, and this is in agreement with the study which reported that human gremlin (GREM1)- overexpressing mice have an increased susceptibility to renal damage, supporting the contribution of gremlin in renal damage progression.
The objective of this study was to evaluate the effects of sodium cyclamate on the kidneys of rat fetuses, in terms of morphometric alterations in the glomerulus, proximal and distal convoluted tubules
and collecting duct.
Collector tubules (tc), degenerate collector tubules (dt), epithelial lining of distal convoluted tubules
(d), infiltrates (inf), molecular region (mr), proximal convoluted tubules (p), renal glomerulus (rg), and vascular congestion (vc).
It is caused by inability of distal convoluted tubules
of the nephron to regulate electrolyte balance owing to mutations, infections, or other causes.
 described the fuses kidney rat of age of 7 days consisting of cortex and the medulla, the cortex contain renal corpuscles and renal tubules, cortical rays contain arteries feeding kidney with little connective tissue, each renal corpuscle contain glomerulus and Bowmans Capsule, renal tubules which consist of proximal convoluted tubules contain columnar cells with basal nucleus and of distal convoluted tubules
contain cubic cells with circular nucleus.
TRMP6 messenger ribonucleic acid, which is expressed in intestinal epithelial cells and kidney tubules, has a crucial role for transcellular [Mg.sup.2+] absorption from the intestine and from the distal convoluted tubules
. Existence of a mutant TRMP6 channel leads to impaired intestinal [Mg.sup.2+] reabsorption and enhanced renal loss (5,6,7,8).
In CIH group, HMGB1 was expressed diffusely in the distended tubular cytoplasms as well as the nuclei of renal tubular epithelial cells, whereas HMGB1 was not or modestly expressed in the nuclei of proximal and distal convoluted tubules
in NA group (Figure 3).
Upon histology, the only significant alteration was vacuolar degeneration and necrosis in the epithelial cells of the distal convoluted tubules
of the kidney.
(1981) observed degeneration and necrosis of tubular epithelial cells of both proximal and distal convoluted tubules
in broiler chicks administered with 95 mg citrinin/kg body weight by crop gavages or mixed with diet.
In hypoplastic fetal and adult kidneys, PAX2 immunoreactivity exhibits less strong nuclear staining in the distal convoluted tubules
and parietal epithelial cells of Bowman capsules.
The urinary organs of females consist of a pair of asymmetric kidneys (right and left) constituted by medullar and cortical region with renal corpuscles and proximal and distal convoluted tubules
beyond collector tubules.