dolichol


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dolichol

[′däl·ə‚kȯl]
(biochemistry)
Any of a group of long-chain unsaturated isoprenoid alcohols containing up to 84 carbon atoms; found free or phosphorylated in membranes of the endoplasmic reticulum and Golgi apparatus.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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[16] Blockage of the cholesterol synthetic pathway affects not only cholesterol synthesis but also other processes, such as the synthesis of isoprenoids, lipid intermediates necessary for protein prenylation; dolichol phosphate, which is involved in protein glycosylation; and ubiquinone, which is involved in respiratory chain activity.
In addition to the effects on cholesterol biosynthesis, statins regulate the synthesis of various other major products such as dolichol, geranyl pyrophosphate, and farnesyl pyrophosphate.
The oligosaccharide was released from dolichol pyrophosphate by mild acid hydrolysis, studied by [sup.1]H-NMR and the structure compared to that deduced for other organisms.31) The reducing N,N-diacetylchitobiose unit and nine mannose residues are present, the latter in equimolar amounts.
The inhibition of the enzyme HMG-CoA reductase, an essential key in the biosynthesis of cholesterol (Medina 2010; Musso et al., 2011), demonstrates to be the key point to reduce cholesterol and several compounds like isopentenyladenine, dolichol, ubiquinone, geranilpirofosfato (GGPP), farnesylpyrophosphate (FPP) (Wong et al., 2007; Gauthaman et al., 2009).
Branch point regulation is an important mechanism controlling carbon flow in the MVAP; the FPP produced by the MVAP can be shunted to many metabolic branches for the synthesis of critical molecules such as ubiquinone, dolichol, or prenylated proteins [59].
Isoprenoid includes cholesterol, bile acids, steroid hormones, dolichol, ubiquinone, prenylated proteins, and a wide variety of plant terpenoids [1].
The lipid dolichol used as a carrier in the first stage of N-glycosylation is a polymer of isoprene units (C[H.sub.3]C(C[H.sub.3])=CH-C[H.sub.2]-) predominantly of 14-17 units in the baker yeast [7], 19-22 in humans [8], and of undetermined length in Candida.
Guan believes dolichol profiling could effectively distinguish RP caused by DHDDS mutation from that caused by other mutations.
Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins.
These isoprenoid lipids are the building blocks for the production of a variety of metabolites, such as dolichol and ubiquinone, but are also required for posttranslational modification (prenylation) of proteins, including small GTPases [11].
The alteration in cell function resulting from the inevitable inhibition of CoQ10 and dolichol is giving us the rest of our broad list of incapacitating adverse effects--the rhabdomyolysis (breakdown of muscle fibers), permanent myopathy (dysfunction of muscle fibers), permanent neuropathy (damage to peripheral nerves) and ALS-like neuromuscular degeneration that has placed many hundreds in wheelchairs--yours truly included.