dosage compensation


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dosage compensation

[′dō·sij ‚käm·pən‚sā·shən]
(genetics)
A mechanism that equalizes the expression in males and females of genes located on the X chromosome, despite their presence in two doses in the homogametic sex and a single dose in the heterogametic sex.
A mechanism that equalizes the expression of X-linked and autosomal genes by doubling the expression level of X-linked genes in male Drosophila and in both male and female mammals with their single active X.
References in periodicals archive ?
Given that male and female heterogametic systems count chromosomes in opposite directions and show different patterns of dosage compensation, the fact that male-killers operate in both these hosts suggests that the X:autosome counting mechanism and the dosage compensation pathway may not be the focus of male-killing activity; rather, somatic sex determination or germ-line sex determination may be the focus.
It enables males to double the expression of the genes in their single X chromosome - a process called dosage compensation - by binding to the body of those genes together with a protein called MOF.
Other topics include regulation of tryptophan biosynthesis in bacillus subtilis, the molecular signatures of natural selection, switches in bacteriophage lambda development, non- homologous end joining in yeast, and chromatin remodeling in dosage compensation.