dosage compensation


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dosage compensation

[′dō·sij ‚käm·pən‚sā·shən]
(genetics)
A mechanism that equalizes the expression in males and females of genes located on the X chromosome, despite their presence in two doses in the homogametic sex and a single dose in the heterogametic sex.
A mechanism that equalizes the expression of X-linked and autosomal genes by doubling the expression level of X-linked genes in male Drosophila and in both male and female mammals with their single active X.
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References in periodicals archive ?
Given that male and female heterogametic systems count chromosomes in opposite directions and show different patterns of dosage compensation, the fact that male-killers operate in both these hosts suggests that the X:autosome counting mechanism and the dosage compensation pathway may not be the focus of male-killing activity; rather, somatic sex determination or germ-line sex determination may be the focus.
Male-Killing Bacteria in Insects: Mechanisms, Incidence, and Implications
It enables males to double the expression of the genes in their single X chromosome - a process called dosage compensation - by binding to the body of those genes together with a protein called MOF.
New protein complex that regulates 4000 genes in fruit fly identified
Other topics include regulation of tryptophan biosynthesis in bacillus subtilis, the molecular signatures of natural selection, switches in bacteriophage lambda development, non- homologous end joining in yeast, and chromatin remodeling in dosage compensation.
Annual review of genetics; v.39, 2005

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