Tumour doubling time
can significantly affect the outcome of anticancer therapy, but the rate is challenging to determine.
Morimoto et al., "Relation of doubling time
of plasma calcitonin levels to prognosis and recurrence of medullary thyroid carcinoma," Annals of Surgery, vol.
The average doubling time
of each cell line is estimated using exponential linear regression on the doubling time
Td=Tlg2/lg(Nt/N0); Td is the doubling time
(h) T is the time taken for cells to proliferate from N0 to Nt (hour) and N is the cell count.
Over 52% of the patients experienced a prolongation of PSA doubling time
(a reflection of slower tumor growth).
In addition we have calculated the doubling time
of all these cell lines in the presence of FBS and CBS.
Quantitative analysis of tumor growth rate and changes in tumor marker level: Specific growth rate versus doubling time
. Acta Oncologica, 48, 591-597.
She unveiled the Green's Vision For Dublin plan which includes doubling time
for pedestrians to cross at traffic lights and a Liffey Valley National Park.
Salvage radiotherapy had to be delivered within 2 years of the biochemical recurrence, and the benefit was limited to men with a prostate-specific antigen (PSA) doubling time
of less than 6 months.
Bone pain in hormone-resistant prostate cancer patients is usually associated with poor Eastern Cooperative Oncology Group (ECOG) performance status, short prostate-specific antigen (PSA) doubling time
, more aggressive disease, and worse prognosis.
Pomegranate juice "is a very non-toxic treatment that, if it really did have that effect on doubling time
, could prevent many people from going on to metastatic disease and hopefully from dying of prostate cancer," he said.