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nonspecific term for an eruption of the skinskin,
the flexible tissue (integument) enclosing the body of vertebrate animals. In humans and other mammals, the skin operates a complex organ of numerous structures (sometimes called the integumentary system) serving vital protective and metabolic functions.
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. It may result from skin allergy, skin irritation, or skin disease, or it may be a symptom of a systemic disease like measles, smallpox, or scarlet fever. A rash may appear as discolored spots or a general redness, or as blisters or pustules, either flat or raised above the surface of the skin. The rash may cause skin irritation—itching, tingling, burning, or pain—or it may not cause any discomfort. The appearance and distribution of a rash are often important factors for consideration in diagnosing a particular disease.
The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved. www.cc.columbia.edu/cu/cup/
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



an eruption on the skin or mucous membrane of man, the cause of which can be either external and internal. Rashes accompany skin and other types of diseases. The external causes can be physical or chemical, while internal causes include diseases of the nervous and hemopoietic systems, metabolic disorders and functional disorders of certain organs (digestion, endocrine glands), infectious diseases (measles, scarlet fever), and allergic reactions (urticaria). Rashes may be primary or secondary. Primary rashes appear on previously normal skin or mucous membrane (spots, wheals, vesicles, pustules, tubercles). Secondary rashes appear as a further development of primary elements (pigmentation, scales, crusts, abrasions, ulcers, fissures, scars). The location, number, combination, color, shape, depth, and duration of the eruptions are helpful in diagnosing the disease.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.


A lay term for nearly any skin eruption, but more commonly for acute inflammatory dermatoses.
(mining engineering)
Very impure coal, so mixed with waste material as to be unsalable.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.


Pathol any skin eruption
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
If the drug rash is benign, treating through may be an option.
The presence of fever in association with a drug rash means that the hypersensitivity reaction is severe and systemic.
SAN FRANCISCO -- More than a quarter of drug-induced liver injury (DILI) cases also involve skin reactions, most often drug rash with eosinophilia and system symptoms (DRESS) syndrome.
Leprosy may be clinically confused with other systemic diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis, sarcoidosis, drug rash, granuloma annulare, granuloma multiforme, pityriasis rotunda, erythema multiforme, and many others (2).
Hung et al., "Clinicopathological features and prognosis of drug rash with eosinophilia and systemic symptoms: a study of 30 cases in Taiwan," Journal of the European Academy of Dermatology and Venereology, vol.
The drug hypersensitivity syndrome associated with Drug Rash, Eosinophilia and Systemic Symptoms, as similar to our case, is called DRESS syndrome.8 The severity of skin symptoms and severity of internal organ involvement may not correlate.9 In our case only hepatic involvement was seen (as suggestive of laboratory findings) with no changes in spleen and in other organs.
Drug rash was seen in 11 (9.2%) of patients (Table 6), of which 8 (6.7%) had maculopapular drug rash, 2 (1.7%) had Stevens-Johnson syndrome and 1 (0.8%) had lichenoid drug reaction (Table 11).
ACDR owing to antepileptics include pruritis, maculopapular and morbilliform rashes, drug rash with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis, erythema multiforme, exfoliative dermatitis, and others.
Hence, drug rash induced by Euthyrox was diagnosed according to the laboratory test results.
Although MPE related with drugs are usually non-severe reactions, more severe and even fatal reactions including Stevens-Johnson syndrome (SJS)/Toxic epidermal necrolysis (TEN) or drug hypersensitivity syndrome (drug rash eosinophilia and systemic symptoms-DRESS) may sometimes occur following this type of reactions (11, 12).
The best intervention for a potentially life-threatening drug rash can happen before you choose a psychotropic.