Although there is no way to equate extinction "trials" in cold tolerance with "placebo" exposures in drug tolerance
, the results of the present experiment may parallel other experiments (Siegel et al., 1980) in that the number of extinction sessions was not sufficient to extinguish tolerance to hypothermia.
is an unavoidable phenomenon in people who take narcotic analgesics over a prolonged period.
The observation of interindividual differences in drug tolerance
is perhaps as old as pharmacotherapy itself.
Results presented at the American Society of Clinical Oncology annual meeting in Chicago, IL, on the clinical activity of amonafide dihydrochloride confirm that genotyping of patients prior to treatment allows for optimized dosing and improved drug tolerance
Occasion setting and drug tolerance
. Integrative Physiological & Behavioral Science, 37, 165-177.
Feedforward processes in drug tolerance
. Perspectives in cognitive neuroscience, 405-416.
slo K+ channel gene regulation mediates rapid drug tolerance
. Proceedings of the National Academy of Sciences of the United States of America 101: 17276-17281, 2004.
Folic acid may also benefit individuals who use the cardiovascular drug nitroglycerin by preventing drug tolerance
(decreased efficacy with use).
It's clear that this reduction underlies drug tolerance
, but how and why does it occur?
The results identify both a mechanism and a potential therapy for drug tolerance
that is induced in the TB bacteria by the host cells they infect.
Relatively high ratios of parent to metabolite drug concentrations, suggestive of naive or intermittent drug use, where significant development of drug tolerance
would be unexpected, were also used to assess the role of these pharmaceuticals in causing death.
Heroin from opiates induces strong mental dependency, and physical dependency and drug tolerance
occurs very early.