The goal of the present research was to determine which additional manipulations might be added to a traditional DRO schedule to produce durable response
elimination in the laboratory.
Secondary endpoints included overall survival, as well as other indicators of efficacy, such as patient-reported outcomes, objective tumor response rate, duration of response, disease control rate, and durable response
The durable response
rate (the proportion of patients with a complete or partial response maintained continuously for at least 6 months), the primary endpoint, was significantly higher among T-VEC--treated patients (16.
a biotechnology company developing cancer immunotherapies, today published online a poster previously presented at the National Cancer Research Institute (NCRI) Cancer Conference in Liverpool that showed axalimogene filolisbac achieved durable response
in a patient with persistent or recurrent metastatic (squamous or non-squamous cell) carcinoma of the cervix (PRmCC).
In phase II, there was a significant response for all dosing cohorts, with a durable response
to 52 weeks," she added.
Treatment with the oncolytic immunotherapy talimogene laherparepvec (T-VEC) resulted in significantly longer rates of durable response
and overall response, compared with subcutaneous granulocyte-macrophage colony-stimulating factor (GM-CSF), according to results from the phase III OPTiM trial reported in the Journal of Clinical Oncology.
Joinlty with the Ministry of Social Affairs (MOSA), LHSP implements since 2013 a comprehensive coordinated and durable response
, for increasing stability and buidling the ability of the communities affected by the Syrian crisis to address tensions, prevent conflict and ensure peaceful co-existence to the effect of the crisis, through improving livelihood and services provision.
The primary efficacy endpoint was the durable response
rate (DRR), defined as the proportion of patients with responses (complete or partial) "maintained continuously for 6 or more months and beginning at any point within 12 months of initiating therapy," as assessed by a blinded independent committee.