Incidental cutaneous reaction patterns: epidermolytic hyperkeratosis, acantholytic
dyskeratosis, and hailey-hailey-like acantholysis: a potential marker of premalignant skin change.
Hereditary benign intraepithelial
dyskeratosis: report of a case and re-examination of the evidence for locus heterogeneity.
Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification.
Other rare diseases which can lead to persistent severe neutropenia including hemophagocytic syndrome, reticular dysgenesis and
dyskeratosis congenita were discounted after an analysis of the bone marrow aspiration findings.
Other disorders to be considered in differential include psoriasis,
dyskeratosis congenita and some of the ectodermal dysplasias.12 Diagnosis of Papillon-Lefevre Syndrome is made by a thorough clinical evaluation that includes a detailed patient history and identification of characteristic physical findings.
All the patients did not have premature graying, blood count abnormalities, or any mucocutaneous features of
dyskeratosis congenita.{Figure 1}{Figure 2}
Therefore, severe dysplasia is characterized by
dyskeratosis and keratin pearls, nuclei changes (hyperchromasia, nuclear pleomorphism, anisonucleosis, increased numbers of nucleoli and mitoses, atypical mitoses) (25).
Only three cases of aplastic anaemia were diagnosed, of which one was due to inherited bone marrow failure syndrome,
Dyskeratosis congenita.
Human diseases that include
dyskeratosis congenita, aplastic anemia, and idiopathic pulmonary fibrosis have been genetically linked to mutations that negatively affect telomerase activity and/or accelerate the loss of telomere length.
More studies brought up that the mutation of RTEL1 had been linked to
dyskeratosis congenital [43], Hoyeraal-Hreidarsson syndrome [44], pulmonary fibrosis [45], myelodysplastic syndrome [46], and lung cancer [47] and even rheumatoid arthritis-associated interstitial lung disease [48].
On final histologic examination, the lesion was found to be a large tumor with verrucous features, hyperkeratosis,
dyskeratosis, and nests of keratin pearl formation (Figure 2).
Caption: Figure 5:
Dyskeratosis with prominent eosinophilic spongiosis and microabscess formation (H&E x400).