cocaine, benzoylecgonine (BZE), ecgonine
methyl ester, norcocaine, have
The half-life of BChE in animal plasma is approximately 21.6 hours (17-19) and it quickly metabolizes the cocaine molecule (20-23) into the metabolite ecgonine
, its derivatives, their salts, isomers, and salts of isomers; or
Using this combined system, the Chemistry Unit developed a method to analyze cocaine, benzoylecgonine, cocaethylene, ecgonine
methyl ester, and ecgonine
in urine and blood.
Results of a postmortem blood sample were positive for cocaine (0.06 mg/L), benzoylecgonine (0.12 mg/L), ecgonine
methyl ester (0.10 mg/L), free morphine (0.27 mg/L), and 6-mono-acetyl-morphine (heroin metabolite) (0.02 mg/L).
They have now isolated from the microbes an enzyme that splits cocaine into benzoic acid and ecgonine
Lack of validity of the KDI Quik Test drug screen for the detection of benzoyl ecgonine
Benzoylecgonine rather than ecgonine
methyl ester was monitored owing to its longer half-life in urine and for compatibility with current drug testing regimes (23, 24).
Simultaneous analysis of ecgonine
methyl ester, benzoylecgonine,
Drug standards [cocaine, benzoylegonine (BZE), ecgonine
methyl ester (EME), cocaine-[D.sub.3], BZE-[D.sub.3] and EME-[D.sub.3]] were prepared from certified reference materials (Cerilliant).
OF was analyzed by GC-MS with 2.5 [micro]g/L LOQs for cocaine, BE, and ecgonine