ectopic expression


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ectopic expression

[ek¦täp·ik iks′presh·ən]
(genetics)
Phenotypic expression of a gene in a type of cell or tissue in which it is usually inactive.
References in periodicals archive ?
This study has led to the identification of a novel factor, whose ectopic expression converts mouse liver cells into pancreatic cells.
Previous studies have shown that perinatal exposure to the synthetic estrogen diethylstilbestrol (DES) leads to feminization of the seminal vesicle (SV) in male mice, as evidenced by tissue hyperplasia, ectopic expression of a major estrogen-inducible uterine secretory protein lactoferrin (LF), and reduced expression of SV secretory IV protein (SVS IV).
Furthermore, high level ectopic expression of these Rab proteins in Leishmania acted as a dominant-negative mutant and impaired the ability of TOR to internalize the trafficking of the adenosine permease.
Ectopic expression of EphB4 in the breast tissue of transgenic mice shows cooperative tumor induction and metastasis with neuT antigen.
Stimulating this receptor signal cascade through ectopic expression of this novel CD40L RNA results in secretion of the downstream inflammatory cytokine IL-12 from the electroporated DCs.
Does ectopic expression of human Cdt1/Cdc6 in cancer cells enhance drug resistance through gene amplification Our findings are expected to offer novel insight into mechanisms underlying cancer development and progression.
BACKGROUND: Studies have shown that perinatal exposure to the synthetic estrogen diethylstilbestrol (DES) leads to feminization of the seminal vesicle (SV) in male mice, as illustrated by tissue hyperplasia, ectopic expression of the major estrogen-inducible uterine secretory protein lactoferrin (LP), and reduced expression of SV secretory protein IV (SVS IV).
DES-treated WT and [beta]ERKO males, but not [alpha]ERKO males, exhibited ectopic expression of LI in the SV.
2000, 2001); ectopic expression of the major estrogen-inducible uterine secretory protein, lactoferrin (LF; also called lacto-transferrin); and loss of constitutive expression of the androgen-regulated gene, SV secretory protein 4 (SVS IV), in the SVs (Beckman et al.
Ectopic expression of Akt induces cell survival and malignant transformation, whereas inhibition of Akt activity stimulates apoptosis in a range of mammalian cells.
Moreover, ectopic expression of rpn-6 protects from the symptoms associated to Huntington s disease.
In addition, the ectopic expression of the protein in endosialin/TEM1-negative cells also mediated cell-cell contact via altered cellular morphology and promoted migration of cells exposed to chemotactic stimuli, both classical characteristics of angiogenesis pathways.