ectopic expression


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ectopic expression

[ek¦täp·ik iks′presh·ən]
(genetics)
Phenotypic expression of a gene in a type of cell or tissue in which it is usually inactive.
References in periodicals archive ?
Ectopic expression of a tomato 9-cis-epoxycarotenoid dioxygenase gene causes overproduction of abscisic acid.
Altogether, ectopic expression of sortilin 1in ovarian carcinoma tissues, its absence in normal human ovary, its involvement in ERK signaling pathway (10) as well as its restricted tissue expression in women makes it a potential candidate for developing more selective targeted therapy approach in patients with ovarian carcinoma.
To the best of our knowledge, this study is the first report describing ectopic expression of sortilin 1 in patients with ovarian carcinoma.
We found that ectopic expression of miR-27a in HepG2 cells significantly suppressed both the mRNA (0.
Does ectopic expression of human Cdt1/Cdc6 in cancer cells enhance drug resistance through gene amplification Our findings are expected to offer novel insight into mechanisms underlying cancer development and progression.
BACKGROUND: Studies have shown that perinatal exposure to the synthetic estrogen diethylstilbestrol (DES) leads to feminization of the seminal vesicle (SV) in male mice, as illustrated by tissue hyperplasia, ectopic expression of the major estrogen-inducible uterine secretory protein lactoferrin (LP), and reduced expression of SV secretory protein IV (SVS IV).
DES-treated WT and [beta]ERKO males, but not [alpha]ERKO males, exhibited ectopic expression of LI in the SV.
2000, 2001); ectopic expression of the major estrogen-inducible uterine secretory protein, lactoferrin (LF; also called lacto-transferrin); and loss of constitutive expression of the androgen-regulated gene, SV secretory protein 4 (SVS IV), in the SVs (Beckman et al.
In WT and [beta]ERKO males, DES exposure resulted in a reduction in SV weight, ectopic expression of Ltf mRNA with a concurrent decrease in Svs4 mRNA expression, and a permanent resistance to androgenic stimulation that was not a result of decreased AR levels; these findings suggest an ER[alpha]-mediated down-stream interference with androgen action as a function of early-life estrogenic exposure.
Ectopic expression of Akt induces cell survival and malignant transformation, whereas inhibition of Akt activity stimulates apoptosis in a range of mammalian cells.
Moreover, ectopic expression of rpn-6 protects from the symptoms associated to Huntington s disease.
In addition, the ectopic expression of the protein in endosialin/TEM1-negative cells also mediated cell-cell contact via altered cellular morphology and promoted migration of cells exposed to chemotactic stimuli, both classical characteristics of angiogenesis pathways.