efflux pump


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efflux pump

[′ē·fləks ‚pəmp]
(cell and molecular biology)
An active transport system for the removal of some antibiotics (such as tetracyclines, macrolides, and quinolones) from bacterial cells.
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References in periodicals archive ?
Other completely different mechanisms such as efflux pumps can lead to exactly the same phenotype.
Rapid multiplexed phenotypic screening identifies drug resistance functions for three novel efflux pumps in Acinetobacter baumannii.
Bernkop-Schnurch, Thiomers: Influence of molecular mass and thiol group content of poly (acrylic acid) on efflux pump inhibition, Intl.
compound antibiotics with efflux pump inhibitors (EPI) probability terminate susceptibility again to antibiotics that before cannot be used.
It has been suggested that extracts capable of potentiating the activity of antibiotics on more than 70% of bacteria could be potential efflux pump inhibitors [70].
Gibbons, "Bacterial efflux pump inhibitors from natural sources," Journal of Antimicrobial Chemotherapy, vol.
Rastegar Lari, "Effect of efflux pump inhibitor carbonyl cyanide 3-chlorophenylhydrazone on the minimum inhibitory concentration of ciprofloxacin in Acinetobacter baumannii clinical isolates," Jundishapur Journal of Microbiology, vol.
Scharenberg, "The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors," Blood, vol.
Project 2 Intrinsic Resistance: Microbiotix will explain how novel pyranopyridine inhibitors of RND-type efflux pump inhibitors exhibit broad spectrum activity against pathogens of the Enterobacteriaceae and favourable pharmacokinetics in mice.