efflux pump


Also found in: Dictionary, Thesaurus, Medical.

efflux pump

[′ē·fləks ‚pəmp]
(cell and molecular biology)
An active transport system for the removal of some antibiotics (such as tetracyclines, macrolides, and quinolones) from bacterial cells.
Mentioned in ?
References in periodicals archive ?
A promising strategy to restore antibiotic effectiveness against pathogens has been the use of a combination of two or more antibiotics or of antibiotics and natural products, and the identification of efflux pump and biofilm inhibitors (Braga et al.
Expression of Efflux Pump MexAB-OprM and OprD of Pseudomonas aeruginosa Strains Isolated from Clinical Samples using qRT-PCR.
aureus is able to acquire resistance to antibiotics and to antiseptic agents via efflux pumps (TetK, msrA transporters) systems, which export certain tetracyclines and macrolides molecules outside the cells.
We hypothesized that the phytochemical may inhibit the extrusion of the common antibiotics as carnosic acid is an efflux pump inhibitor by dissipation of the membrane potential in S.
A variety of resistance mechanisms have been identified in P aeruginosa, including enzyme production, overexpression of efflux pumps, porin deficiencies, and target-site alterations.
1996) Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis.
Molecular Detection of Aminoglycoside resistance Mediated by Efflux Pump and Modifying Enzymes in Pseudomonas aeruginosa isolated from Iraqi Hospitals.
Efflux pumps are transport proteins involved in the expulsion of toxic substrates (including virtually all classes of clinically relevant antibiotics) from within cells into the external environment.
In two isolates, this was the only genotypic trait detected, while, in seven other isolates, it was associated with upregulation of the MexAB-OprM efflux pump (two isolates) or with the presence of [beta]-lactamase [bla.
A very recent study from India showed high level (upto 80%) of expression of drug efflux pumps in E.
New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate.
Strategies to overcome MDR resistance mechanisms include combination therapies of two or more antibiotics, or combining an antibiotic with a bacterial resistance-modifying agent, such as efflux pump inhibitors, to increase the activity of the antibiotic.