efflux pump


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efflux pump

[′ē·fləks ‚pəmp]
(cell and molecular biology)
An active transport system for the removal of some antibiotics (such as tetracyclines, macrolides, and quinolones) from bacterial cells.
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To assess the potential activity of the 13 compounds as efflux pump inhibitors, a real-time EtBr accumulation assay in a S.
Drug Efflux Pump Expression Analysis In one ASCO poster presentation (abstract #11108), researchers presented an analysis of drug efflux pump expression in more than 50,000 molecularly profiled patients with solid tumors.
The alkaloids reserpine and berberine are examples of plant-derived efflux pump inhibitors from plants; they were able to potentiate the activity of fluoroquinolones and tetracyclines against resistant bacteria (Gibbons et al.
110 efflux pump inhibitors two-fold reduction in MIC was seen in 57-100 per cent M.
Several mechanisms are thought to be involved in the development of resistance to chemotherapy, including overexpression of the membrane-associated ATP-dependent efflux pump, P-glycoprotein, which is encoded by MDR1 and MRP1 (8, 9).
If so, efflux pump inhibitors might be able to shorten the duration of curative treatment for TB.
VceR regulates the vceCAB drug efflux pump operon of Vibrio cholerae by alternating between mutually exclusive conformations that bind either drugs or promoter DNA.
Practical applications and feasibility of efflux pump inhibitors in the clinic-A vision for applied use.
The efflux pump (mefA gene) is the most common in Spain.
aureus SA-1199B (harboring resistance to fluoroquinolones through overexpression of the NorA efflux pump is ciprofloxacin resistant (Kerns et al.
The paper, led by Edward Yu of Iowa State University and the Ames Laboratory, describes the co-crystal structure of two parts of the three-part efflux pump that recognizes and removes heavy metal toxins from bacteria.
Efflux pump mediated multidrug resistance has become a significant complicating factor in the chemotherapy of bacterial infections.