2][alpha], deficiency is associated with impaired eicosanoid
biosynthesis, small intestinal ulceration, and platelet dysfunction.
sativa exerts its anti-inflammatory action may be related to its ability to inhibit eicosanoid
0 [micro]M) acts as an inhibitor of the expression of mPGES-1, a terminal synthase that functions downstream to COX-2 for eicosanoid
production, cooperatively induced by ET-1 and the pathogen in heart muscle cells (Fig.
Various markers of airway inflammation and oxidative stress such as cytokines, eicosanoids
, nitric oxide, urates, and hydrogen peroxide have been shown to be increased in EBC of patients with asthma.
11,12,13) Short chain EFA-Omega (6) (Linoleic Acid) and Omega 3 (Alpha linolenic acid) with the help of enzymes desaturase and elongase are converted to Long Chain Fatty Acids, AAArachidonic Acid, GLA-Gamma linolenic acid, DGLA-DihomoGLA, EPA-Eicosapentaenoic Acid, DHA- Docosahexaenoic Acid which are further converted to eicosanoids
(PGProstaglandins, PGI-Prostacyclins, TX-Thromboxane by the enzyme Cyclooxygenase and LT-Leukotrienes by the enzyme15-Lypoxygenase).
Inhibitors of eicosanoid
biosynthesis influencing the transcripts level of sHSP21.
Smith, The eicosanoid
and their biochemical mechanisms of action, Biochemical Journal, 259(2), 315-324 (1989).
sphingoids (as part of MxP[TM] Lipids), MxP[TM] Catecholamines, and MxP[TM] Eicosanoids
Therefore, supplementation with MPL is expected to be more effective in a relatively lower dose than fish oil or ethyl ester formulations regarding eicosanoid
synthesis and its implications.
The immunosuppression caused by high LNA inclusion or the unbalanced n-3/n-6 ratio in this diet has already been reported in other fish species and may have been caused by changes in eicosanoid
production (SARGENT et al.
Some studies have recognized the effects of n-3 PUFA via eicosanoid
pathway in cancer prevention, while others have implicated the role of dietary fat in changing the androgen milieu as a causative factor for prostate cancer.
The regulation of eicosanoid
production occurs, in part, via the coordinated spatial-temporal expression of associated enzymatic pathways that vary according to cell type and upon the state of cellular activation.