eicosanoid


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eicosanoid

[ī′käs·ə‚nȯid]
(biochemistry)
Any member of a group of naturally occurring substances composed of prostaglandins, thromboxanes, and leukotrienes that are derived from polyunsaturated fatty acids, particularly arachidonic acid, and exhibit various types of biological activity.
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Omega-3-rich fish oil rebalances the eicosanoid pathway and safely helps reduce inflammation.
They also interfere with maturation and differentiation of the stratum corneum and inhibit production of proinflammatory eicosanoids, reactive species (ROS and RNS), and cytokines, thus influencing the inflammatory response and possibly wound healing [35-38].
All samples were performed in quadruplicate and the results were expressed as the mean of the eicosanoid concentration [+ or -] SD.
(2008) Inherited human c[PLA.sub.2][alpha], deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction.
sativa exerts its anti-inflammatory action may be related to its ability to inhibit eicosanoid generation.
Powell, "Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney.
Also, we found that Cur (13.5-27.0 [micro]M) acts as an inhibitor of the expression of mPGES-1, a terminal synthase that functions downstream to COX-2 for eicosanoid production, cooperatively induced by ET-1 and the pathogen in heart muscle cells (Fig.
Various markers of airway inflammation and oxidative stress such as cytokines, eicosanoids, nitric oxide, urates, and hydrogen peroxide have been shown to be increased in EBC of patients with asthma.[sup][3],[4],[5],[6],[7] The method of collecting EBC is easy, and the cost is low.
(11,12,13) Short chain EFA-Omega (6) (Linoleic Acid) and Omega 3 (Alpha linolenic acid) with the help of enzymes desaturase and elongase are converted to Long Chain Fatty Acids, AAArachidonic Acid, GLA-Gamma linolenic acid, DGLA-DihomoGLA, EPA-Eicosapentaenoic Acid, DHA- Docosahexaenoic Acid which are further converted to eicosanoids (PGProstaglandins, PGI-Prostacyclins, TX-Thromboxane by the enzyme Cyclooxygenase and LT-Leukotrienes by the enzyme15-Lypoxygenase).
Inhibitors of eicosanoid biosynthesis influencing the transcripts level of sHSP21.4 gene induced by pathogen infections, in Antheraea pernyi.
The Effects of Butyrate on TLR-Signalling Mediators and the Eicosanoid Pathway.
Oral green tea catechin metabolites are incorporated into human skin and protect against UV radiation-induced cutaneous inflammation in association with reduced production of pro-inflammatory eicosanoid 12-hydroxyeicosatetraenoic acid.