eicosanoid


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eicosanoid

[ī′käs·ə‚nȯid]
(biochemistry)
Any member of a group of naturally occurring substances composed of prostaglandins, thromboxanes, and leukotrienes that are derived from polyunsaturated fatty acids, particularly arachidonic acid, and exhibit various types of biological activity.
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Impact of EPA ingestion on COX-and LOX-mediated eicosanoid synthesis in skin with and without pro-inflammatory UVR-challenge-report of a randomized controlled study in humans.
Some studies have recognized the effects of n-3 PUFA via eicosanoid pathway in cancer prevention, while others have implicated the role of dietary fat in changing the androgen milieu as a causative factor for prostate cancer.
A second level of regulation, which determines the specific eicosanoid produced following PGH2 production, is via the expression of intermediate and terminal enzymes, which include cPGES and mPGES, prostacyclin synthase, and brain or hematopoietic isoforms of prostaglandin D synthase (bPGDS, hPGDS).
One example is arachidonic acid, a FFA found in cell membranes, that is used to synthesise prostaglandins and other eicosanoids.
Most of the functions of oxylipins derived from arachidonic acid, also called eicosanoids, are well known and primarily associated with immuno-stimulatory events (which stimulate the immune system) and pro-coagulant actions (which promote blood coagulation).
These fatty acids are important structural and physiological components of cell membranes and thought to play an important role in permeability, enzyme activity, eicosanoid metabolism and the maintenance of membranes (Bell et al.
When the in-vitro effects of transresveratrol, some wine-derived phenol compounds, and some antioxidants were studied, a blockage in platelet aggregation and eicosanoid synthesis in human cells was observed, contributing to the cardioprotective effect of resveratrol, mainly against atherosclerosis in coronary disease patients.
Odd-chain fatty acid and eicosanoid precursor C20 PUFAs were detected by flame ionization gas chromatography only sporadically; they were in low titres.
Founded in 2005 and headquartered in San Diego, Amira Pharmaceuticals is a small molecule pharmaceutical company focused on the discovery and early development of compounds to treat inflammatory disease linked to the eicosanoid pathway.
MCCARTY, MF 1996: Fish oil may impede tumour angiogenesis and invasiveness by down-regulating protein kinase C and modulating eicosanoid production.