Plasma phospholipid elaidic acid
concentrations, the main TFA isomer occurring during partial hydrogenation of vegetable oils found in a myriad of industrial foods, were positively associated with the intake of highly processed foods within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort [44,45].
Ohno et al., "Association between serum elaidic acid
concentration and insulin resistance in two japanese cohorts with different lifestyles," Journal of Atherosclerosis and Thrombosis, vol.
Template formations with other C18 fatty acids are also tested, namely, oleic acid (cis-9-octadecenoic acid) and elaidic acid
"Coupling to elaidic acid
improves the bioavailability of the agent without impeding its epigenetic effect," explained project leader Frank Lyko.
Schaefer (2002) reported that the presence in the diet of elaidic acid
, which contains trans double bonds, is associated with increased low-density lipoprotein (LDL) levels and decreased high-density lipoprotein (HDL) levels.
Plasma lipoprotein lipid and Lp (a) changes with substitution of elaidic acid
for oleic acid in the diet.
(B) Comparison with an authentic sample of the isomeric elaidic acid
supports this assignment.
However, in plasma samples, the retention time of the TBDMS ester of oleic acid was very similar to that of its trans isomer, elaidic acid
. This would interfere with tracer measurements because we administer the [[1.-sup.13]C]-labeled cis isomer (oleic acid).
Stock solutions of juvenile hormone III (JH III), MF, phorbol- 12,13 dibutyrate (PDBU), 1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine (H-7), arachidonic acid, elaidic acid
, verapamil, 4-aminopyridine, and nigericin were prepared in 95% ethanol.
These are oleic acid (cis 18:1[Delta]9) and elaidic acid
Another TFA, elaidic acid
, could influence arachidonic acid metabolism, playing an important role in formation of athermanous plaque .
The predominant unsaturated fatty acids obtained were oleic acid and elaidic acid
up to 57%.