Elastase


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elastase

[i′la‚stās]
(biochemistry)
An enzyme which acts on elastin to change it chemically and render it soluble.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Elastase

 

an enzyme of the hydrolase class elaborated by the pancreas of animals including humans. Elastase catalyzes the splitting of peptide bonds in proteins, chiefly those between the radicals of neutral animo acids. It is particularly active against elastin. The enzyme is secreted in the form of inactive proelastase, which is converted to elastase by the enzyme trypsin. Elastase is found in some bacteria.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
The elastase lasB has a role in the degradation of host collagen and non-collagen proteins, thus damaging the physical barrier of host and facilitating the dissemination of i nfection.21 High-level production of elastase was detected in vitro among most of P.
Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia.
The ability of the NSS oil samples to inhibit porcine pancreatic elastase (PPE) was determined by measuring the release of p-nitroaniline from N-succinyl-(Ala)3-p-nitroanilide spectrophotometrically according to the method of Bieth et al (1974) with slight modifications.
Further, an immunofluorescence study of NETs showed that NETs consist of azurophilic (primary) granules such as cathepsin G, neutrophil elastase, and myeloperoxidase.
The MPO ANCA in patients with hydralazine-induced vasculitis is often in high titer, and patients often have antibodies directed to other antigens for perinuclear, elastase, and lactoferrin (8, 12, 13).
Plasma levels of biomarkers, including HMGB1, MCP-1, interleukin-6 (IL-6), plasma neutrophil elastase, and CC16, were measured and compared between the baseline ([T.sub.1], after anesthesia induction), 1 h after resumption of two-lung ventilation from OLV ([T.sub.2]), and postoperative day 1 ([T.sub.3]).
Fecal elastase measurements were performed after the patients were qualified to participate in the study according to endosonography findings.
Histological analysis revealed evident airspace enlargement and obliteration of the alveolar wall in the lungs injected with elastase. These changes were attenuated by the instillation of MSCs (Figure 2(a)).
The second aim of this study is to investigate the xanthine oxidase, tyrosinase, elastase, and neuraminidase inhibition effect of these S-substituted perhalonitrobuta-1,3-diene compounds.
Abbreviations G-CSF: Granulocyte colony-stimulating factor HAX1: HS1-associated protein X1 ELANE: ELA2 elastase, neutrophil expressed SCN: Severe congenital neutropenia.
With low levels of circulating SerpinA1, the lungs are not protected from neutrophil elastase, an enzyme that destroys alveoli and causes lung disease.