In summary, a breach of the elastic lamina
by tumor appears to indicate a worse outcome.
Control Native heart Heart graft Morphometry Elastic lamina
area 16.4 [+ or -] 5.7 148.6 [+ or -] 136.4 ([mm.sup.2]) Arterial lumen area 16.4 [+ or -] 5.7 11.4 [+ or -] 12.8 ([mm.sup.2]) % Stenosis 0 90.8 [+ or -] 9.5 Immunohistochemistry % Macrophage 0.04 [+ or -] 0.07 27.13 [+ or -] 21.07 LDE-MTX Native heart Heart graft Morphometry Elastic lamina
area 12.6 [+ or -] 2.8 * 179.6 [+ or -] 166.2 ([mm.sup.2]) Arterial lumen area 12.6 [+ or -] 2.8 * 40.4 [+ or -] 29.8 ** ([mm.sup.2]) % Stenosis 0 72.6 [+ or -] 11.2 *** Immunohistochemistry % Macrophage 0.04 [+ or -] 0.09 5.97 [+ or -] 4.05 ** All animals were treated with cyclosporine A (10 mg x [kg.sup.-1] x [day.sup.-1]).
Studies using transmission electron microscopyhave reported that between 1 and 4 hours after graft surgery, there is evidence of endothelial damage with cell loss, and the internal elastic lamina
is observed as a discontinuous and amorphous line of elastin.
In foetus of last trimester, children of 1st and 2nd decade elastic fibres were long, parallel and closely packed with circularly arranged smooth muscle cells running between elastic lamina
. Increase in number of lamellae was also noticed with each decade.
Thick segments elastic lamina
in alternate with region of deposited regions of ectasia collagen and medial thinning Angiographic appearance Focal or tubular String of beads appearance appearance Adventitial FMD Vascular Layer Affected Adventitia or Medial- Adventitial Junction Frequency 5%-10% Pathology of lesion 1.
(5) The transgenic mice develop a diffuse vasculopathy with intimal hypertrophy, primarily a result of smooth-muscle proliferation, disruption of the elastic lamina
and fibrosis of the media and adventitia--findings similar to those seen in HIV-associated vasculopathy.
The perimeter and area of the lumen, the length of the internal elastic lamina
and the area it enclosed, the length of the outer limit of the media and the area it enclosed were measured on each arterial section (Figure 1).
The special elastin stain highlights the fragmentation of the internal elastic lamina
in this vessel (hematoxylin-eosin, original magnifications X20 [A and B]; original magnification X20 [C]).
Internal Elastic Lamina
(IEL) defects before penetration of the durmater and near the branching of the PICA may be related to the development of dissection at these sites.
IT was defined as the distance from the lumen- vessel interface to the interface between the internal elastic lamina
and the media IMT as the distance from the lumen-vessel interface to the interface between the media and the external elastic lamina
and MT was calculated as the difference between IMT and IT.
Similar changes occur in the connective tissue of the media and intima of the blood vessels, Bruch's membrane of the eye, and in the endocardium and pericardium.3,4,5 Calcification of the internal elastic lamina
of the arteries leads to vascular occlusion.
Cerebral arteries have been shown to possess a poorly developed external elastic lamina
and adventitia, thin media and defects in the media termed Forbus raphes (Forbus, 1930; Finlay & Ganhan, 1994; Laadzinki et al., 1996).