electrochemical gradient


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Related to electrochemical gradient: electrochemical proton gradient

electrochemical gradient

[i‚lek·trō‚kem·i·kəl ′grād·ē·ənt]
(cell and molecular biology)
The combined effect of a solute's concentration gradient across a membrane and the electric charge gradient across the membrane (the membrane potential), which drives the solute to cross the membrane.
References in periodicals archive ?
The NADH and [FADH.sub.2] molecules produced cannot be utilized unless CoQ10 is available within the ETC to accept their electrons to create the electrochemical gradient. Dissipation of the electrochemical gradient results in the inability to pump hydrogen ions into the intermembrane space.
"We identified an unexpected and critical function of p53 in activating necrosis: In response to oxidative stress in normal healthy cells, p53 accumulates in the mitochondrial matrix and triggers the opening of the PTP pore at the inner mitochondrial membrane, leading to collapse of the electrochemical gradient and cell necrosis," Moll said.
The movement of electrons through the ETC proteins provides energy for hydrogen ions to be pumped against a concentration gradient producing an electrochemical gradient. ATP synthase (a membrane-bound protein) then uses the dectrochemical gradient to produce ATP by capturing the energy of the hydrogen ions flowing down the concentration gradient.

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