electrophile


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electrophile

[i′lek·trō‚fīl]
(physical chemistry)
An electron-deficient ion or molecule that takes part in an electrophilic process.
References in periodicals archive ?
High EHOMO is essential for reaction with nucleophiles of molecule while low ELUMO is essential for reaction with electrophiles [44].
This is because the electrophiles, produced when antioxidants are oxidized, prime the increase of the nucleophilic tone.
The electrophilicity index ([omega]) is another important parameter [55] which measures the propensity of chemical species to accept electrons; a high value of electrophilicity index describes a good electrophile while a small value of electrophilicity indicates a good nucleophile.
Our quantitative analysis of the reactivity of redox-sensitive TRP channels revealed that TRPA1 has the highest sensitivity to disulphides among the TRPs that we tested, predicting that only TRPA1 responds to a relatively inert electrophile, diallyl disulphide, with a redox potential of -2,950 mV.
Yamamoto, "Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles," Free Radical Biology & Medicine, vol.
This carbon in an isocyanate is an electrophile that makes it highly reactive.
Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis.
The vast majority of RCS, including 4-HNE and MDA, modulate transcription through the Keap1-Nrf2 pathway, which regulates the electrophile response element/antioxidant response element (EpRE/ARE) [33, 88, 93].
Subsequent tuning of the reactivity and specificity of the electrophile resulted in the discovery of a class of highly selective Btk inhibitors within the cysteine homolog family.
(29.) Talalay P, Dinkova-Kostova AT, Holtzclaw WD: Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis.