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Moreover, human GSTP1-1 exhibits protective role mainly against the cytotoxic effects of some electrophilic agents, and their metabolites (Sun et al.
In MEP analysis, electrophilicity and nucleophilicity is explained on the basis of different color codes, red color indicates nucleophilic and blue color reflects electrophilic site [43].
68) Specific Cys residues of TRPA1 are capable of reacting with many of these compounds via electrophilic Michael addition.
It plays an important role in detoxification by catalyzing the conjugation of many drophobic and electrophilic compounds with reduced glutathion.
Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury.
43) GSTs are well known phase II detoxification enzymes which catalyze reactions between reduced glutathione and electrophilic substrates.
Keap1 contains cysteine residues that interact with reactive oxygen species (ROS) and electrophilic fragments that can trigger the dissociation of the Keap1-Nrf2 complex (Zhang and Hannink 2003).
Generally, PAEKs can be prepared via one of two routes, the nucleophilic or the electrophilic aromatic substitution polycondensation [9-11].
DPRA is designed to mimic the covalent bonding of electrophilic chemicals (sensitizers) to nucleophilic domains present in skin proteins.
Paracetamol metabolite, N-acetyl-p-benzoquinone imine (NAPQI) is a reactive electrophilic that induces tissues impairment,[18] indicated with the increase of MDA levels in the serum.
On the other hand, recent studies have indicated that cancer cells hijack the ability of NRF2 to survive under the oxidative or electrophilic conditions.
The intracellular depletion of reduced glutathione can be either due to the formation of a direct complex with a electrophilic agent or due to the inhibition of synthesis or due to the subjection of the cell to oxidative stress.