electrophilic


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electrophilic

[i¦lek·trō′fil·ik]
(physical chemistry)
Pertaining to any chemical process in which electrons are acquired from or shared with other molecules or ions.
Referring to an electron-deficient species.
References in periodicals archive ?
Is electrophilic or can be Parent compound or metabolite with metabolically activated an electrophilic structure (e.g., epoxide, quinone, etc.), formation of DNA and protein adducts.
This behavior can be understood considering that both [O.sub.3] and HO* present a strong electrophilic nature, which considerably facilitates the attack at the chromophore centers.
Furan groups may also participate in the polymerization mechanism through electrophilic substitution reactions, as reported in previous work involving the polymerization of benzoxazines containing furan groups [22, 24].
In this figure, the color code red to yellow indicates regions of low electrostatic potential and is related to electrophilic reactivity, while blue to green indicates regions of high electrostatic potential related to nucleophilic reactivity sites.
The maximum values of relative nucleophilicity index ([s.sup.+.sub.k]/[s.sup.-.sub.k]) and relative electrophilicity index ([s.sup.-.sub.k]/[s.sup.+.sub.k]) are used to define, respectively, the probable sites of nucleophilic and electrophilic attacks.
We proposed that the furan group of LIM played an important role in the LIM-induced inhibition of the activity of drug-metabolizing enzymes and/or transporters, and specifically this LIM is metabolized to the corresponding cis-enedial (Scheme 1, cisenedial 3), and the resulting electrophilic metabolites are responsible for the quench of many drug-metabolizing enzyme activities.
It can be easily seen from the results for the dual descriptor [DELTA]f (r) in Figure 3 that C13 will be the preferred site for a nucleophilic attack and that this atom will act as an electrophilic species in a chemical reaction.
There are negative charges on nitrogen atoms, [C.sub.2] and [C.sub.4,] and positive charges on [C.sub.1], [C.sub.3] and [C.sub.5,] showing no difference with which have been known that electrophilic substitution reaction (e.g.
Accumulating evidence suggests that redox reactive species, including reactive oxygen species (ROS), reactive nitrogen species (RNS) and other electrophilic molecules, serve as signaling molecules that regulate biological and physiological processes.
Through conjugation with glutathion, it functions in the detoxification of environmental toxins and products of oxidative stress, electrophilic compounds, including carcinogens and therapeutic drugs.