electrophilic


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electrophilic

[i¦lek·trō′fil·ik]
(physical chemistry)
Pertaining to any chemical process in which electrons are acquired from or shared with other molecules or ions.
Referring to an electron-deficient species.
References in periodicals archive ?
In each case, vinyl ether groups react with hydroxyl groups of the Br[Phi]nsted acid-based binder polymer at high temperature by electrophilic addition reaction to form a crosslinked network with an acetal structure.
Moreover, human GSTP1-1 exhibits protective role mainly against the cytotoxic effects of some electrophilic agents, and their metabolites (Sun et al.
In MEP analysis, electrophilicity and nucleophilicity is explained on the basis of different color codes, red color indicates nucleophilic and blue color reflects electrophilic site [43].
5,] showing no difference with which have been known that electrophilic substitution reaction (e.
Accumulating evidence suggests that redox reactive species, including reactive oxygen species (ROS), reactive nitrogen species (RNS) and other electrophilic molecules, serve as signaling molecules that regulate biological and physiological processes.
Through conjugation with glutathion, it functions in the detoxification of environmental toxins and products of oxidative stress, electrophilic compounds, including carcinogens and therapeutic drugs.
Samples of nineteen chapters are: general concepts for covalent bonding and constructing Lewis structures for organic molecules; guideline for writing organic molecule isomers and determining number of rings plus pi-bonds; notation in organic chemistry; guide to writing and using condensed formulas and line drawings; summary guidelines for organic nomenclature; summary guide to thermodynamic concepts for organic chemistry; guide to stereochemistry concepts and analysis of reaction stereochemistry as applied to electrophilic addition; a brief guideline for applying fundamental concepts in NMR spectroscopy.
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1.
Some drugs are metabolized and converted into active toxic metabolites under the action of CYP450, such as electrophilic group, free radical, and oxygroup, which can covalently bind macromolecular substances including protein, nucleic acid, and lipid, causing lipid peroxidation and final hepatocyte necrosis.
Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products.
As it is known, carbon tetrachloride that is converted with the cytochrome P-450 in free radicals and electrophilic intermediates is aggressive hepatotoxin.
In addition to their ability of conjugation of non-polar compounds carrying electrophilic centers (i.