Normal seminiferous tubule showing complete maturation of spermatozoa (A), germ cell neoplasia in situ (GCNIS) (B,C), GCNIS showing pagetoid spread into rete testis (D), intratubular seminoma (E), and intratubular embryonal carcinoma
with abundant necrosis (F) (hematoxylin-eosin, original magnifications X400 [A and C] and X200 [B, D, E, F]).
Aberrant results were received in cases of dysgerminoma, yolk sac tumour and embryonal carcinoma
. This stresses the importance of using positive control for all markers and adding newer markers in the study panel.
Rizzino, "Differential activity of the FGF-4 enhancer in F9 and P19 embryonal carcinoma
cells," Journal of Cellular Physiology, vol.
First, it was a rare case of mixed germ cell tumors with components of Endodermal Sinus Tumor and embryonal carcinoma
which is the least common (16%) component of germ cell tumors (5).
Since Akt activation is often deregulated in cancer and Oct4 expression is upregulated in cancer stem cells of various types of cancer, the researchers are studying whether the Akt/Oct4 pathway plays similar roles in other types of cancer stem cells in addition to embryonal carcinoma
Despite the fact that SNTCSs do not contain elements of either yolk sac tumor, germinoma, choriocarcinoma, or embryonal carcinoma
, (2,5,13,14) some authors (1,2,15) have postulated that they arise from germ cells or neural crests.
It can also label large B cell lymphoma, other T cell lymphomas, and non-lymphoid tumours like embryonal carcinoma
. ALCL is a group of large cell lymphoma of T/null cell origin strongly expressing CD30 on cell membrane and Golgi region.
The tumours are classified into seminoma (classic, anaplastic and spermatocytic variants) and non-seminomatous germ cell tumours (embryonal carcinoma
, teratocarcinoma, teratoma, choriocarcinoma, and yolk sac tumours).
Yolk sac tumor, embryonal carcinoma
, choriocarcinoma, and combined nonteratomatous germ cell tumors of the mediastinum--a clinicopathologic and immunohistochemical study of 64 cases.
More than two decades ago, it was discovered that when treated with RA, the human embryonal carcinoma
cell line NT2 differentiates irreversibly into several morphologically and phenotypically distinct cell types, which include terminally differentiated postmitotic CNS neurons [45-46].
In April 2000, he had been admitted to urology clinic because of painless left testicular mass and diagnosed as having metastatic testicular embryonal carcinoma
with normal beta human chorionic gonadotropin KG) levels and markedly elevated levels of a-fetoprotein (9204 IU/mL, normal: 0.5-5.0).