Papillary structures in an embryonal carcinoma
simulate Schiller-Duval sinuses.
It is similarly important to distinguish seminoma from yolk sac tumors because yolk sac tumors, like embryonal carcinoma
, are radioresistant.
Congenital teratomas are commonly immature and often contain an admixed yolk sac tumor and, rarely, embryonal carcinoma
Ki-1 (CD30) antigen is regularly expressed in tumor cells of embryonal carcinoma
lacks the 3 different types of cells described in spermatocytic seminoma.
Genetic reprogramming is believed to contribute to the development of NSGCTs from GCNIS or a seminoma cell via transformation to an embryonal carcinoma
cell, although the mechanisms underlying this transformation are unclear.
There was difficulty in distinguishing embryonal carcinoma
from dysgerminoma, as both gave positive results with OCT4.
Of those, seminoma (classical type), embryonal carcinoma
, and teratocarcinoma were reported in five, one, and one patient, respectively.
14 NHL: Non-Hodgkin lymphoma, MFH: Malignant fibrous histiocytoma, MNS GCT: Malignant nonseminomatous germ cell tumor, TT: Testicular tumors, TB: Tuberculosis, EMB Ca: Embryonal carcinoma
, UT: Undecided testis, MM GCT: Malignant Mixed Germ Cell Tumour, NFWAAL: Neurofibroma with Atypical Lipoma, TaWSC: Testis abscess With Suppurative Changes Table 2: Histopathological diagnosis along with age distribution Age group MM GCT Seminoma MNS GCT TeratoCa 10-20 1 1 21-30 2 1 2 31-40 2 41-50 1 2 51-60 61-70 >70 Total 1 6 1 4 Age group Embryonal MFH NHL Total 10-20 2 21-30 5 31-40 2 41-50 1 4 51-60 0 61-70 1 1 2 >70 0 Total 1 1 1 15 NHL: Non-Hodgkin lymphoma, MFH: Malignant fibrous histiocytoma, MNS GCT: Malignant nonseminomatous germ cell tumor
This patient was diagnosed with mixed germ cell tumor with predominant yolk sac tumor and embryonal carcinoma
Mixed germ cell tumor with components of Endodermal Sinus Tumor and embryonal carcinoma
were reported by histological examination (Figures 1 and 2).
Histopathology exam reported one microscopic focus of embryonal carcinoma
engulfed in fibrosis and necrosis.