The specific rotation of the synthesized compounds was determined and the result obtained showed that the enantiomerically
enriched compounds were dextrorotary isomers, indicating primarily that the enantiomerically
enriched complexes are in excess of the dextrorotary isomer.
When polarized light passes through a solution containing an enantiomerically
pure compound, the light emerges with its plane of polarization changed.
Taiyo International, Inc., Minneapolis, MN, has received an official "letter of no objection" from the FDA regarding the self-affirmed GRAS (generally recognized as safe) status of its enantiomerically
pure L-theanine, marketed as Suntheanine, produced via a patented enzymatic fermentation method.
One possibility of preparing compound 2 is to start from 2-oxabicyclo[3.3.0]oct-6-en-3-one (Grieco lactone) 1 , which is a commercially readily available product, in enantiomerically
pure form and in multigram scale [11-14].
Used to resolve chiral compounds from racemic mixtures into pure enantiomers, SMB capability is one of the fastest methods to obtain enantiomerically
pure drugs, increasingly important as the demand for single-enantiomer drugs continues to grow.
This made it more effective than polymer 5 in reducing acetophenone to yield a more enantiomerically
enriched product mixture.
Other biochemically important hydroxyacids, i.e., D/L-lactate, D/L-glycerate, and D/L-3hydroxybutyrate, can also be separated enantiomerically
by use of DATAN as the derivatizing reagent, without the need to change chromatographic conditions (data not shown).
Design that lessens therapeutic doses without increasing overall potency is already occurring with the emphasis on enantiomerically
pure drugs (homochiral drugs), which can have therapeutic advantages over their conventional racemic mixtures.
In addition, progress on the synthesis of enantiomerically
pure chiral bromosilanes using tartrate-based, chiral N-bromosuccinimide derivatives will be presented.
(MOEC), of Watervliet, N.Y., have reportedly found a way to use enantiomerically
pure chiral molecules to make polymers with optical properties four times as stable as the properties of polymers made with conventional precursors.
Thus, chiral drugs extracted from plants and animals are enantiomerically