When polarized light passes through a solution containing an enantiomerically
pure compound, the light emerges with its plane of polarization changed.
They were able to introduce a chiral twist into these materials by inserting an enantiomerically
pure (one-handed) chiral monomer, such as indane bisphenol (IBP) or spirobiindane (SBI), into the polymer backbone.
Thus, chiral drugs extracted from plants and animals are enantiomerically
The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically
pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis.
In this project, we propose to develop an industrially scalable, practical method for the synthesis of a-arylated quaternary amino acids in enantiomerically
pure form by streamlining, optimization and scale-up of a reaction we discovered while working on the synthesis of quaternary amino acids as conformational controllers within an ERC-funded Advanced Grant.
As is well known, discovery of the existence of enantiomeric isomers of organic compounds as well as their isolation as enantiomerically
pure isomers with the use of tweezers under microscope were performed for the preparation of enantiomerically
pure D-(-)- and L-(+)-tartaric acids as early as the mid-nineteenth century by L.
Chiral epoxides are very important building blocks for the synthesis of enantiomerically
pure molecules of biologically active compounds and pharmaceuticals [1-3].
Enzymatic resolution of a racemate is also a widely used method to obtain enantiomerically
enriched compounds [6, 7].
This assay uses pseudo-prochiral (H5, D5) malonate diesters, which need only be enantiomerically
enriched, which is hydrolyzed under a variety of conditions and monitored by LDI-TOF or ESI-MS.
The direct synthesis of three enantiomerically
pure diastereomers of a 1-ferrroceylalkylamine from 1-(-)-menthone and the up-down-stereoisomerism of ferrocene derivatives.
Indeed, the stereoselective epoxidation of achiral and chiral allylic alcohols using enantiomerically
pure titanium-tartrate complexes is known as the Sharpless reaction.
In addition, progress on the synthesis of enantiomerically
pure chiral bromosilanes using tatrate-based, chiral N-bromosuccinimide derivatives will be presented.