This work presents a new method for the asymmetric synthesis of [gamma]-halo-[delta]-lactones 3, 5, 7 substrates for the synthesis of 6,6-dimethyl-4-isopropyl-3-oxabicydo [3.1.0] hexan-2-one as a source of
enantiomerically pure cischrysanthemic acid.
As is well known, discovery of the existence of enantiomeric isomers of organic compounds as well as their isolation as
enantiomerically pure isomers with the use of tweezers under microscope were performed for the preparation of
enantiomerically pure D-(-)- and L-(+)-tartaric acids as early as the mid-nineteenth century by L.
Chiral epoxides are very important building blocks for the synthesis of
enantiomerically pure molecules of biologically active compounds and pharmaceuticals [1-3].
More than 50% of the top 100 drugs are based on
enantiomerically pure molecules and such drugs already today exhibit sales exceeding 100 billion US-Dollars.
The use of
enantiomerically pure DOTAP Chloride shows enhanced adjuvant activity compared to the racemate.
Some specific processes described include chemoenzymatic routes to
enantiomerically pure amino acids and amines, multi-enzyme systems for the synthesis of glycoconjugates, and microbial production of DNA building blocks.
In their March 2007 cover article in Angewandte Chemie International Edition 46 (2007), 2276, the U of A researchers show that using
enantiomerically pure (R) propylene oxide, each of the 6 conformers is "frozen out" in their molecular beam and can be observed by their distinct rotational spectrum (see Figure 3).
Taiyo International, Inc., Minneapolis, MN, has received an official "letter of no objection" from the FDA regarding the self-affirmed GRAS (generally recognized as safe) status of its
enantiomerically pure L-theanine, marketed as Suntheanine, produced via a patented enzymatic fermentation method.
In addition, progress on the synthesis of
enantiomerically pure chiral bromosilanes using tartrate-based, chiral N-bromosuccinimide derivatives will be presented.
(MOEC), of Watervliet, N.Y., have reportedly found a way to use
enantiomerically pure chiral molecules to make polymers with optical properties four times as stable as the properties of polymers made with conventional precursors.
Thus, chiral drugs extracted from plants and animals are
enantiomerically pure.