technotrain has the specific objective to develop general, Reproducible and also profitable, Stereoselective, Catalytic synthetic methods applicable for industrial production of enantiomerically pure
, Functionalized amino derivatives featuring a quaternary stereocenter.
This work presents a new method for the asymmetric synthesis of [gamma]-halo-[delta]-lactones 3, 5, 7 substrates for the synthesis of 6,6-dimethyl-4-isopropyl-3-oxabicydo [3.1.0] hexan-2-one as a source of enantiomerically pure
As is well known, discovery of the existence of enantiomeric isomers of organic compounds as well as their isolation as enantiomerically pure
isomers with the use of tweezers under microscope were performed for the preparation of enantiomerically pure
D-(-)- and L-(+)-tartaric acids as early as the mid-nineteenth century by L.
Chiral epoxides are very important building blocks for the synthesis of enantiomerically pure
molecules of biologically active compounds and pharmaceuticals [1-3].
More than 50% of the top 100 drugs are based on enantiomerically pure
molecules and such drugs already today exhibit sales exceeding 100 billion US-Dollars.
The use of enantiomerically pure
DOTAP Chloride shows enhanced adjuvant activity compared to the racemate.
Some specific processes described include chemoenzymatic routes to enantiomerically pure
amino acids and amines, multi-enzyme systems for the synthesis of glycoconjugates, and microbial production of DNA building blocks.
In their March 2007 cover article in Angewandte Chemie International Edition 46 (2007), 2276, the U of A researchers show that using enantiomerically pure
(R) propylene oxide, each of the 6 conformers is "frozen out" in their molecular beam and can be observed by their distinct rotational spectrum (see Figure 3).
Taiyo International, Inc., Minneapolis, MN, has received an official "letter of no objection" from the FDA regarding the self-affirmed GRAS (generally recognized as safe) status of its enantiomerically pure
L-theanine, marketed as Suntheanine, produced via a patented enzymatic fermentation method.
In addition, progress on the synthesis of enantiomerically pure
chiral bromosilanes using tartrate-based, chiral N-bromosuccinimide derivatives will be presented.
(MOEC), of Watervliet, N.Y., have reportedly found a way to use enantiomerically pure
chiral molecules to make polymers with optical properties four times as stable as the properties of polymers made with conventional precursors.
Thus, chiral drugs extracted from plants and animals are enantiomerically pure