In collaboration with Ding, the lab of Olivier Voinnet at the Swiss Federal Institute of Technology in Zurich also reported in an accompanying paper the detection of viral siRNAs in cultured mouse embryonic stem cells infected by the Encephalomyocarditis
The cardioviruses (family Picornaviridae, genus Cardiovirus) are pathogens of rodents and include a murine encephalomyocarditis
virus and Theiler's virus and related strains (species Theilovirus), the latter serving as laboratory models of the pathogenesis of multiple sclerosis in mice (1).
For this, murine encephalomyocarditis
virus (EMCV)-sensitive L 929 fibroblasts were incubated with different amounts of EPs[R] 7630 and some characteristic constituents, respectively, before exposure to EMCV suspensions.
Data presented from an in vitro study comparing the antiviral effect of VX-497 in combination with interferon-alpha to that of ribavirin in combination with interferon-alpha showed the VX-497/interferon-alpha combination was more potent against the encephalomyocarditis
To the Editor: Cardioviruses currently consist of at least 3 viruses: Theiler murine encephalomyocarditis
virus, and Saffold virus (SAFV) (1-4).
Interferon activity was assessed as capacity to protect murine L929 fibroblasts from the cytopathic effect of murine encephalomyocarditis
virus (EMCV, generously provided by Prof.
In another study, VX-497 was shown to have 15-to 40-fold more potent antiviral activity in combination with interferon-alpha, compared to a combination of ribavirin plus interferon-alpha, in cells infected with encephalomyocarditis
Gender-determined differences in susceptibility to virus infections have been reported for encephalomyocarditis
virus (34), vesicular stomatitis virus (35), and coxsackievirus B3 (36).
A wild-type porcine encephalomyocarditis
virus containing a short poly (C) tract is pathogenic to mice, pigs, and cynomolgus macaques.
The measured in vitro antiviral activities of Echinacea sap in cultures of mouse L-cells against Encephalomyocarditis
(EMC) virus or vesicular-stomatitis virus (VSV) were observed only when the sap was added together with DEAE-dextran.