endochondral ossification


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endochondral ossification

[¦en·dō′kän·drəl ‚äs·ə·fə′kā·shən]
(physiology)
The conversion of cartilage into bone. Also known as intracartilaginous ossification.
References in periodicals archive ?
Endochondral ossification occurs at the medial border and lateral angle of the scapula, where OC commonly develops.
Some studies suggested that AA, a classic n-6 PUFA, has been reported to inhibit endochondral ossification and bone mineralization through activating inflammatory factors like PGE-2 and LTs [20, 21].
In the present study, we focused on the tissue-specific distribution of the TPD52 and TPD54 in bone and cartilage tissue in vivo and the cell-specific physiological roles of those proteins on proliferation and differentiation of chondrocytes in endochondral ossification in vitro.
[sup][9],[10],[11],[12],[13] Other important genes and transcription factors involved in signaling pathways related to selected endochondral ossification included the following: DKK1 in the Wnt signaling pathway; BMP6 , BMP4 , and BMP2 in the BMP signaling pathway; DMP1 and MGP in the matrix mineralization pathway; IHH in the hedgehog signaling pathway; and RUNX2 - and SRY-related high mobility group-box gene 9 in transcription factors related to ossification.
At week 1 post-fracture, in the control group, moderate staining for BMP-2 was seen in osteogenic cells, fibroblast-like cells or chondrocytes, osteoblasts in the subperiosteal bone, proliferating chondrocytes and osteoblasts in the trabecular bone near the endochondral ossification front.
HOA1 (hydroxyacid oxidase 1) on 20p12.3, RSPO2 (R-spondin 2) on 8q23.1 and CCDC91 (coiled-coil domain containing 91) 12p11.22 are implicated in the endochondral ossification process.
Theories such as aberrant joint loading and issues with epiphyseal endochondral ossification have also been suggested to contribute to the proposed multifaceted etiology of JOCD of the knee.
Endochondral ossification of retained fetal bones is the most widely accepted aetiological hypothesis.