Localization of nitric oxide synthase isoforms (I, II and III) in the endolymphatic sac
of the guinea pig.
SLC26A4 is normally found in the cochlea and vestibular organs of the inner ear as well as in the endolymphatic sac
, which is a non-sensory part of the inner ear.
An endolymphatic sac
tumor was ultimately confirmed by histologic correlation following operative resection.
tumors: The endolymphatic sac
is located in the inner ear within the vestibular aqueduct.
The pathologic findings include multiple HABs (usually retinal, cerebellar, or spinal), RCC, pheochromocytoma, islet cell tumors of the pancreas, endolymphatic sac
tumors of the inner ear, and papillary cystadenomas of the epididymis or broad ligament, as well as cysts and other benign neoplasms of the pancreas, kidney, and liver.
Low-grade adenocarcinoma of probable endolymphatic sac
This condition is believed to be caused by an elevated level of endolymphatic pressure, which is likely due to poor absorption from the endolymphatic sac
or excess secretion of endolymph, and results in distention of Reissner's membrane.
All except 2 cases demonstrated apical petrous temporal bone invasion on imaging, and it has been suggested that they arose from a primary endolymphatic sac
tumor, which has a similar papillary epithelial histology.
This condition resolves with either (1) the release of en dolymph through the endolymphatic sac
, (2) the reaccumulation of perilymph through the aqueduct, or (3) perhaps another mechanism.
To summarize, they are the use of the operating microscope, tympanoplasty and mastoidectomy techniques, stapes surgery, endolymphatic sac
surgery for intractable Meniere's disease, skull base surgery (for example, removal of vestibular schwannomas, vestibular nerve sections), use of intratympanic gentamycin, and cochlear implantation, not to mention the discovery of new diseases.
Patients with an endolymphatic sac
tumor (ELST) typically present with palsy of cranial nerves VII and/or VIII; other presenting symptoms include hearing loss, otalgia, occipital headaches, cranial nerve palsies, vertigo, gait ataxia, tinnitus, and otorrhea.
20) They used intraoperative topical mitomycin C in 14 patients with Meniere's disease who were undergoing endolymphatic sac
mastoid shunt surgery.