ARID1A mutations were observed in 55 of 119 ovarian clear cell carcinoma (46%), 10 of 33 endometrioid carcinomas
(30%), and none of the 76 high-grade serous ovarian carcinomas.
Results: PTEN alteration and NDRG1 expressions were significantly increased in the ischaemic area of endometrioid carcinoma
compared with their expressions in the normal endometrium respectively (P<0.
Although the presence of focal glandular differentiation can help in separating endometrial endometrioid adenocarcinoma, FIGO grade 3, from pure forms of UEC, this feature loses its power in cases of mixed forms of UEC or dedifferentiated carcinoma, where the UEC component is mostly seen admixed with lower-grade endometrioid carcinoma
of the ovary with a prominent spindle-cell component, a source of diagnostic confusion: a report of 14 cases.
When endometrioid adenocarcinomas profiled in the earlier gene expression analysis were annotated with mutational status of genes affecting these pathways (Figure 2, F), it was discovered that ovarian endometrioid carcinomas
with deregulated Wnt and/or PI3K/Akt signaling were the ones readily separable from the serous carcinomas.
Clinicopathologic features and genetic alterations in endometrioid carcinoma
of the uterus with villoglandular differentiation.
Cases Staining Staining PCNA glandular Endometrioid carcinoma
20 7 (53) 13 (65) Serous carcinoma 10 3 (30) 7 (70) Clear cell carcinoma 10 2 (20) 8 (80) PCNA stroma Endometrioid carcinoma
20 7 (53) 13 (65) Serous carcinoma 10 3 (30) 7 (70) Clear cell carcinoma 10 2 (20) 8 (80) Mean SD P Value PCNA glandular Endometrioid carcinoma
Molecular abnormalities frequently observed in endometrioid carcinoma
include early PTEN and K-ras mutations, microsatellite instability, and late p53 mutations.
A tumor with this feature is often dedifferentiated EC, which comprises FIGO (Federation Internationale de Gynecologie et d'Obstetrique) grade 1 or 2 endometrioid carcinomas
and undifferentiated carcinomas (19, 22).
A diagnosis of endometrioid carcinoma
was rendered (original magnifications X10 [A, hematoxylin-eosin]), X40 [B, hematoxylin-eosin], and X20 [C through F]).
A significant positive correlation was found between VEGF expression and binary grading which is an architectural grading system that uses low-magnification assessment of amount of solid growth, pattern of invasion, and presence of necrosis to divide endometrioid carcinomas
into low- and high-grade tumors.
The tumors' expression of these markers was compared based on ethnicity and tumor type (Type I = endometrioid carcinomas
, hormone-related tumors and Type II = non-endometrioid carcinomas
, non-hormone related tumors which are more clinically aggressive).