The selective ability of FOR-6219 to inhibit local estrogen production in the endometrium
and endometriotic lesions, without suppressing systemic estrogen levels, is unique and expected to be the key differentiator against competing endometriosis therapies.
Transvaginal ultrasonography is used to measure thickness of endometrium
. This should be thinner in post menopausal women (70 years###2###5.7
However, the regulatory mechanism of LIF and LIFR expression in the endometrium
is not fully understood in pigs.
000001, the summary random effects were significant in 35 meta-analyses 31 of these found increased risk with adiposity of esophageal adenocarcinoma, multiple myeloma, and cancers of the colon, rectum, liver, biliary tract system (cancers of gallbladder, extrahepatic bile duct, and ampulla of Vater), pancreas, postmenopausal breast, endometrium
, and kidney.
Hysteroscope was inserted into the uterine cavity alongside the endometrium
line finally and hysteroscope was used to perform pushing and blunt dissection in the uterine cavity, so that the filmy adhesions could be separated completely, the uterine cavity came back to normal form and the whole uterine cavity and openings of the bilateral fallopian tubes could be observed [Figure 1].
The uterus was bulky and contained thick endometrium
. Cervix was normal.
In the present study, atrophic endometrium
was found in 12.2%.
In 1925 Neumann for the first time described the presence of hyaline cartilage in the fundus of uterus between endometrium
and myometrium; the reason of hysterectomy was pelvic inflammatory disease.1 After that Taylor and Roth published a detailed case series and considered possible causes of heterotopic cartilage within the myometrium.2 They witnessed that each of their cases of heterotopia was associated with either endometriosis or endometritis, suggesting metaplasia as the prime cause of heterotopia.2 Metaplasia is replacement of one type of tissue with another and is a normal response to chronic inflammation, tissue damage, repair and regeneration.1 Endometrium
is the commonest site of cartilaginous heterotopia.
The simplest and widely used measure is the thickness of the endometrium
and the junctional zone for the morphological analysis of uterus on the medical images.
Estrogens were administered to the poor responder patients until the endometrium
thickness grew at least to 8 mm.
According to various studies conducted in different parts of Pakistan, atrophic endometrium
is the commonest cause of postmenopausal bleeding with a prevalence rate of 12-16%.4,5
The infections can spread to the uterus and cause thinning of the endometrium
, thereby creating a barrier in development of the fetus.