endonuclease


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endonuclease

[¦en·dō′nü·klē‚ās]
(biochemistry)
Any of a group of enzymes which degrade deoxyribonucleic acid or ribonucleic acid molecules by attaching nucleotide linkages within the polynucleotide chain.
References in periodicals archive ?
moshkovskii-specific nested SSU-rDNA gene amplification products were digested with restriction endonuclease XhoI for one hour at 37 [degrees]C according to the instructions of the manufacturer (Promega) to verify the identity of species.
The number of copies of the transgenic cassette from plasmid PV-ZMIR13 was determined by digesting event MON863 genomic DNA with the restriction endonuclease EcoRV, an endonuclease that cuts only once in the linear DNA fragment from plasmid PV-ZMIR13 used to generate the event (Fig.
Three endonucleases (Bcl I, Bgl II, Pst I) produced a single pattern in all birds examined, whereas all other endonucleases produced two or more patterns (Appendix 1); 78 haplotypes were found among the 272 individuals.
To evaluate all random insertional mutants of Psm, the chromosomal DNA of many mutants was subjected to complete endonuclease restriction, and then analyzed through PFGE.
However, the presence of these mutations, including substitutions and missense mutations, did not affect the restriction-enzyme cutting sites of other endonucleases (Hinc II, Acc I, and PflM I; Fig.
The endonuclease enables the virus to trick someone into producing viral proteins, which join into new viruses that spread the infection.
This protein is thought to be homologous to the Endonuclease G (EndoG) of higher eukaryotes, responsible for DNA degradation in caspase-independent processes of programmed cell death (10,11).
Two phase II trials of gefitinib are underway in patients with squamous cell carcinoma and topical therapies on the horizon include T4 endonuclease V, a bacterial DNA repair enzyme that increases the rate of repair of sunlight-induced DNA damage in human cells, Dr.
The number of scored fragments ranged from 2 (rpS14-cob with endonuclease TaqI) to 14 (psbC-trnS with endonuclease HaeIII) (Table 3).
Apurinic/apyrimidinic (AP) endonuclease 1 (Ape1) is the major mammalian abasic endonuclease and initiates repair of this cytotoxic/mutagenic lesion by incising the DNA backbone via a [Mg.
Another agent in clinical development that may have a "field effect" in treating AKs is T4 endonuclease V, a DNA repair enzyme that may also restore p53 gene function.