enkephalin


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enkephalin

(ĕnkĕf`əlĭn), one of several naturally occurring morphinelike substances (endorphinsendorphins
, neurotransmitters found in the brain that have pain-relieving properties similar to morphine. There are three major types of endorphins: beta endorpins, found primarily in the pituitary gland; and enkephalins and dynorphin, both distributed throughout the nervous
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) released from nerve endings of the central nervous system and the adrenal medulla. They act as analgesics and sedatives in the body and appear to affect mood and motivation.

enkephalin

[en′kef·ə·lən]
(biochemistry)
A mixture of two polypeptides isolated from the brain; central mode of action is an inhibition of neurotransmitter release.
References in periodicals archive ?
Striatal enkephalin and dynorphin opioid systems mediate reward and negative affect, respectively, and are relevant to addiction disorders.
Biological inactivation of enkephalins and the role of enkephafn-dipepddyl-carboxypeptidase ("enkephafnase") as neuropepddase.
The availability of endogenous opioid peptides, endorphins, enkephalins and dynorphins, led to the characterization of the opioid receptor subtypes, mu, delta, and kappa.
Degeneration occurs in the spiny neurons enriched in gamma aminobutyric acid (GABA) and enkephalin that project to the external globus pallidus.
As adults, in times of calm or isolation, their enkephalin levels would drop, creating a relative withdrawal state with an increase in tension and dysphoria.
These nanoparticles of surface carboxylic acid groups were then covalently linked to peptides such as the syntheric tripeptide enkephalin (1-3, Tyr-Gly-Gly), via carbodiimide coupling, to form amide bonds.
Immunocytochemical localization of enkephalin and substance P in retina and eyestalk neurones of lobster.
Enkephalins have been defined into two naturally occurring types called methionine enkephalin and leucine enkephalin.
Nicholas Bodor and his colleagues at the University of Florida in Gainesville sandwiched a naturally occurring pain-relief protein called enkephalin between a fatty acid and a molecule that becomes positively charged in the presence of enzymes found in the brain.
Diamyd Medical AB has reported that the Phase II study evaluating the Company's drug candidate NP2 Enkephalin did not meet the primary objective of reducing pain in subjects with severe intractable cancer pain.
Peripheral analgesic action of clonidine: mediation by release of endogenous enkephalin like substances.