Peptide-T, an entry inhibitor
first discovered in the 1980s but not studied as an anti-HIV drug until the late '90s, is also so well tolerated that codeveloper Pert says one possible use for the drug would be for patients on so-called drug holidays--periods when they stop taking anti-HIV drugs in order to reduce toxic side effects.
The debut of entry inhibitors
has been eagerly awaited because of preclinical hints that they may be highly effective and have few side effects.
With a far greater understanding of the HIV cell entry process, we can now envisage HIV entry inhibitors
as whole new classes of drugs for the future.
The four new anti-HIV drugs that came out in 2003 are Fuzeon, part of a new class of drugs called entry inhibitors
or fusion inhibitors; the protease inhibitors Reyataz and Lexiva; and the reverse transcriptase inhibitor Emtriva.
We also saw data about other new classes of drugs, including many other entry inhibitors
, CCR-5 inhibitors, and one drug from a completely new class that may be a viral assembly inhibitor.
RITA: Some people view the entry inhibitors
in development as the next great hope in HIV treatments, possibly replacing some classes of antiretroviral agents as first-line treatments: a second-generation HAART, if you will.
Classes of entry inhibitors
include coreceptor inhibitors (these block HIV's interaction with coreceptors such as the chemokines CCR5 and CXCR4) and fusion inhibitors (these prevent the virus from fusing with the cell membrane).
Among the new classes of drugs under study are HIV integrase inhibitors, which block the enzyme that HIV uses to incorporate its genetic material into human DNA, and HIV entry inhibitors
, which prevent the virus from entering the cell.
The Second Collaborative Research Seminar on HIV and Other Viral Entry Inhibitors
, May 3-5, 2002, The Waldorf Astoria, New York, NY The Macrae Group, 230 East 79th St, Suite 8E, NY 10021, 212-988-7732 212-7171222 macraegrp@binternet.
Doms, who also envisions using several classes of entry inhibitors